The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. Export

@article{citeulike:562082, abstract = {The isolation, characterization, and expression of a full-length cDNA encoding the human T cell glycoprotein CD6 is described. COS cells transfected with the CD6 clone express a 90-kD protein that reacts with all available anti-CD6 monoclonal antibodies. RNA blot hybridization analysis indicates that CD6 transcripts are predominantly restricted to cells in the T lineage. The predicted CD6 sequence is 468 amino acids long, with the typical features of a type I integral membrane protein. The cytoplasmic domain of CD6 contains two serine residues, one or both of which are substrates for phosphorylation during T cell activation. The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. These molecules, therefore, constitute a new gene superfamily that is well conserved across species boundaries.}, address = {Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.}, author = {Aruffo, A. and Melnick, M. B. and Linsley, P. S. and Seed, B.}, citeulike-article-id = {562082}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/1919444}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=1919444}, day = {1}, issn = {0022-1007}, journal = {J Exp Med}, keywords = {cd6, structure}, month = {October}, number = {4}, pages = {949--952}, posted-at = {2006-03-24 08:55:53}, priority = {0}, title = {The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1919444}, volume = {174}, year = {1991} }

TY - JOUR ID - citeulike:562082 L3 - citeulike-article-id:562082 N2 - The isolation, characterization, and expression of a full-length cDNA encoding the human T cell glycoprotein CD6 is described. COS cells transfected with the CD6 clone express a 90-kD protein that reacts with all available anti-CD6 monoclonal antibodies. RNA blot hybridization analysis indicates that CD6 transcripts are predominantly restricted to cells in the T lineage. The predicted CD6 sequence is 468 amino acids long, with the typical features of a type I integral membrane protein. The cytoplasmic domain of CD6 contains two serine residues, one or both of which are substrates for phosphorylation during T cell activation. The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. These molecules, therefore, constitute a new gene superfamily that is well conserved across species boundaries. IS - 4 JF - J Exp Med SN - 0022-1007 AD - Department of Molecular Biology, Massachusetts General Hospital, Boston 02114. EP - 952 TI - The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. VL - 174 SP - 949 KW - cd6 KW - structure AU - Aruffo, A AU - Melnick, MB AU - Linsley, PS AU - Seed, B PY - 1991/10/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/1919444 ER -