The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Export

@article{citeulike:562088, abstract = {SIT is a transmembrane adapter protein that modulates signals emanating from the T-cell receptor (TCR). Here, we have used gene-targeted mice to assess the role of SIT for T-cell development and peripheral T-cell functions. SIT(-/-) double-positive thymocytes show an upregulation of the activation markers CD5 and CD69, suggesting that SIT negatively regulates TCR-mediated signals at the CD4(+) CD8(+) stage of thymic development. This assumption is further supported by the observation that in female H-Y TCR transgenic mice, positive selection is enhanced and even converted to negative selection. Similarly, mature peripheral T cells are hyperresponsive towards TCR-mediated stimuli and produce larger amounts of T-helper 1 (TH1) cytokines, and SIT-deficient mice show an increased susceptibility to develop experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. These results demonstrate that SIT is a critical negative regulator of TCR-mediated signaling and finely tunes the signals required for thymic selection and peripheral T-cell activation.}, address = {Otto von Guericke University, Institute of Immunology, Magdeburg, Germany. luca.simeoni@medizin.uni-magdeburg.de}, author = {Simeoni, L. and Posevitz, V. and K\"{o}lsch, U. and Meinert, I. and Bruyns, E. and Pfeffer, K. and Reinhold, D. and Schraven, B.}, citeulike-article-id = {562088}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/MCB.25.17.7557-7568.2005}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16107703}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16107703}, doi = {10.1128/MCB.25.17.7557-7568.2005}, issn = {0270-7306}, journal = {Mol Cell Biol}, keywords = {adapter, cell, protein, sit, t, thymus}, month = {September}, number = {17}, pages = {7557--7568}, posted-at = {2006-03-24 08:59:24}, priority = {2}, title = {The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.}, url = {http://dx.doi.org/10.1128/MCB.25.17.7557-7568.2005}, volume = {25}, year = {2005} }

TY - JOUR ID - citeulike:562088 L3 - citeulike-article-id:562088 N2 - SIT is a transmembrane adapter protein that modulates signals emanating from the T-cell receptor (TCR). Here, we have used gene-targeted mice to assess the role of SIT for T-cell development and peripheral T-cell functions. SIT(-/-) double-positive thymocytes show an upregulation of the activation markers CD5 and CD69, suggesting that SIT negatively regulates TCR-mediated signals at the CD4(+) CD8(+) stage of thymic development. This assumption is further supported by the observation that in female H-Y TCR transgenic mice, positive selection is enhanced and even converted to negative selection. Similarly, mature peripheral T cells are hyperresponsive towards TCR-mediated stimuli and produce larger amounts of T-helper 1 (TH1) cytokines, and SIT-deficient mice show an increased susceptibility to develop experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. These results demonstrate that SIT is a critical negative regulator of TCR-mediated signaling and finely tunes the signals required for thymic selection and peripheral T-cell activation. IS - 17 JF - Mol Cell Biol SN - 0270-7306 AD - Otto von Guericke University, Institute of Immunology, Magdeburg, Germany. luca.simeoni@medizin.uni-magdeburg.de EP - 7568 TI - The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. VL - 25 SP - 7557 KW - adapter KW - cell KW - protein KW - sit KW - t KW - thymus AU - Simeoni, L AU - Posevitz, V AU - Kölsch, U AU - Meinert, I AU - Bruyns, E AU - Pfeffer, K AU - Reinhold, D AU - Schraven, B PY - 2005/09// UR - http://dx.doi.org/10.1128/MCB.25.17.7557-7568.2005 ER -