CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. Export

@article{citeulike:562096, abstract = {Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of CD5 surface expression during normal thymocyte ontogeny and in mice with developmental and/or signal transduction defects. The results demonstrate that low level expression of CD5 on CD4(-)CD8(-) (double negative, DN) thymocytes is independent of TCR gene rearrangement; however, induction of CD5 surface expression on DN thymocytes requires engagement of the pre-TCR and is dependent upon the activity of p56(lck). At the CD4(+)CD8(+) (double positive, DP) stage, intermediate CD5 levels are maintained by low affinity TCR-major histocompatibility complex (MHC) interactions, and CD5 surface expression is proportional to both the surface level and signaling capacity of the TCR. High-level expression of CD5 on DP and CD4(+) or CD8(+) (single positive, SP) thymocytes is induced by engagement of the alpha/beta-TCR by (positively or negatively) selecting ligands. Significantly, CD5 surface expression on mature SP thymocytes and T cells was found to directly parallel the avidity or signaling intensity of the positively selecting TCR-MHC-ligand interaction. Taken together, these observations suggest that the developmental regulation of CD5 in response to TCR signaling and TCR avidity represents a mechanism for fine tuning of the TCR signaling response.}, address = {Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.}, author = {Azzam, H. S. and Grinberg, A. and Lui, K. and Shen, H. and Shores, E. W. and Love, P. E.}, citeulike-article-id = {562096}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9858516}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9858516}, day = {21}, issn = {0022-1007}, journal = {J Exp Med}, keywords = {cd5, cell, singnal, t, tcr}, month = {December}, number = {12}, pages = {2301--2311}, posted-at = {2006-03-24 09:16:30}, priority = {2}, title = {CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9858516}, volume = {188}, year = {1998} }

TY - JOUR ID - citeulike:562096 L3 - citeulike-article-id:562096 N2 - Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of CD5 surface expression during normal thymocyte ontogeny and in mice with developmental and/or signal transduction defects. The results demonstrate that low level expression of CD5 on CD4(-)CD8(-) (double negative, DN) thymocytes is independent of TCR gene rearrangement; however, induction of CD5 surface expression on DN thymocytes requires engagement of the pre-TCR and is dependent upon the activity of p56(lck). At the CD4(+)CD8(+) (double positive, DP) stage, intermediate CD5 levels are maintained by low affinity TCR-major histocompatibility complex (MHC) interactions, and CD5 surface expression is proportional to both the surface level and signaling capacity of the TCR. High-level expression of CD5 on DP and CD4(+) or CD8(+) (single positive, SP) thymocytes is induced by engagement of the alpha/beta-TCR by (positively or negatively) selecting ligands. Significantly, CD5 surface expression on mature SP thymocytes and T cells was found to directly parallel the avidity or signaling intensity of the positively selecting TCR-MHC-ligand interaction. Taken together, these observations suggest that the developmental regulation of CD5 in response to TCR signaling and TCR avidity represents a mechanism for fine tuning of the TCR signaling response. IS - 12 JF - J Exp Med SN - 0022-1007 AD - Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. EP - 2311 TI - CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. VL - 188 SP - 2301 KW - cd5 KW - cell KW - singnal KW - t KW - tcr AU - Azzam, HS AU - Grinberg, A AU - Lui, K AU - Shen, H AU - Shores, EW AU - Love, PE PY - 1998/12/21/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9858516 ER -