Negative regulation of CD4 lineage development and responses by CD5. Export

@article{citeulike:562099, abstract = {CD5 deficiency results in a hyper-responsive phenotype to Ag receptor stimulation. Here we show that the development and responses of CD4 lineage T cells are regulated by the function of CD5. Thymocytes expressing the I-Ad-restricted DO11.10 TCR undergo abnormal selection without CD5. In H-2d mice, the absence of CD5 causes deletion of double-positive thymocytes, but allows for efficient selection of cells expressing high levels of the DO11.10 clonotype. By contrast, there is enhanced negative selection against the DO11.10 clonotype in the presence of I-Ab. T cell hybridomas and DO11.10 T cells are more responsive to TCR stimulation in the absence of CD5. Such hypersensitivity can be eliminated by expression of wild-type CD5, but not by a form of CD5 that lacks the cytoplasmic tail. Finally, CD5 deficiency partially suppresses the block of CD4 lineage development in CD4-deficient mice. Taken together, the data support a general role for CD5 as a negative regulator of Ag receptor signaling in the development and immune responses of CD4 lineage T cells.}, address = {Department of Microbiology and Immunology, University of California, San Francisco 94143, USA.}, author = {Pe\~{n}a-Rossi, C. and Zuckerman, L. A. and Strong, J. and Kwan, J. and Ferris, W. and Chan, S. and Tarakhovsky, A. and Beyers, A. D. and Killeen, N.}, citeulike-article-id = {562099}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10586041}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10586041}, day = {15}, issn = {0022-1767}, journal = {J Immunol}, keywords = {cd4, cd5, regulation}, month = {December}, number = {12}, pages = {6494--6501}, posted-at = {2006-03-24 09:18:49}, priority = {0}, title = {Negative regulation of CD4 lineage development and responses by CD5.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10586041}, volume = {163}, year = {1999} }

TY - JOUR ID - citeulike:562099 L3 - citeulike-article-id:562099 N2 - CD5 deficiency results in a hyper-responsive phenotype to Ag receptor stimulation. Here we show that the development and responses of CD4 lineage T cells are regulated by the function of CD5. Thymocytes expressing the I-Ad-restricted DO11.10 TCR undergo abnormal selection without CD5. In H-2d mice, the absence of CD5 causes deletion of double-positive thymocytes, but allows for efficient selection of cells expressing high levels of the DO11.10 clonotype. By contrast, there is enhanced negative selection against the DO11.10 clonotype in the presence of I-Ab. T cell hybridomas and DO11.10 T cells are more responsive to TCR stimulation in the absence of CD5. Such hypersensitivity can be eliminated by expression of wild-type CD5, but not by a form of CD5 that lacks the cytoplasmic tail. Finally, CD5 deficiency partially suppresses the block of CD4 lineage development in CD4-deficient mice. Taken together, the data support a general role for CD5 as a negative regulator of Ag receptor signaling in the development and immune responses of CD4 lineage T cells. IS - 12 JF - J Immunol SN - 0022-1767 AD - Department of Microbiology and Immunology, University of California, San Francisco 94143, USA. EP - 6501 TI - Negative regulation of CD4 lineage development and responses by CD5. VL - 163 SP - 6494 KW - cd4 KW - cd5 KW - regulation AU - Peña-Rossi, C AU - Zuckerman, LA AU - Strong, J AU - Kwan, J AU - Ferris, W AU - Chan, S AU - Tarakhovsky, A AU - Beyers, AD AU - Killeen, N PY - 1999/12/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/10586041 ER -