An influence of CD5 on the selection of CD4-lineage T cells. Export

@article{citeulike:562100, abstract = {Combining CD5-null, MHC-deficient and lineage-specific reporter animals, we have investigated the influence of CD5 on positive selection and the choice of CD4- versus CD8-lineage commitment on broad populations of thymocytes. CD5 has no obvious quantitative effect in wild-type mice. In mice lacking MHC class II molecules, however, increased numbers of transitional, class I-selected CD4+ CD8(int) CD3(hi) cells were positively selected in the absence of CD5. Importantly, they were committed to the CD4 lineage. Our results indicate that CD5 negatively regulates the differentiation of CD4-committed cells in suboptimal conditions, thus perhaps serving to tighten the correlation between restriction of the TCR and lineage choice.}, address = {Institut de G\'{e}n\'{e}tique et de Biologie Mol\'{e}culaire et Cellulaire (CNRS/INSERM/ULP) Illkirch, C.U. de Strasbourg, France.}, author = {Chan, S. and Waltzinger, C. and Tarakhovsky, A. and Benoist, C. and Mathis, D.}, citeulike-article-id = {562100}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10508266}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10508266}, issn = {0014-2980}, journal = {Eur J Immunol}, keywords = {cd4, cd5, cell, t}, month = {September}, number = {9}, pages = {2916--2922}, posted-at = {2006-03-24 09:19:51}, priority = {2}, title = {An influence of CD5 on the selection of CD4-lineage T cells.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10508266}, volume = {29}, year = {1999} }

TY - JOUR ID - citeulike:562100 L3 - citeulike-article-id:562100 N2 - Combining CD5-null, MHC-deficient and lineage-specific reporter animals, we have investigated the influence of CD5 on positive selection and the choice of CD4- versus CD8-lineage commitment on broad populations of thymocytes. CD5 has no obvious quantitative effect in wild-type mice. In mice lacking MHC class II molecules, however, increased numbers of transitional, class I-selected CD4+ CD8(int) CD3(hi) cells were positively selected in the absence of CD5. Importantly, they were committed to the CD4 lineage. Our results indicate that CD5 negatively regulates the differentiation of CD4-committed cells in suboptimal conditions, thus perhaps serving to tighten the correlation between restriction of the TCR and lineage choice. IS - 9 JF - Eur J Immunol SN - 0014-2980 AD - Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP) Illkirch, C.U. de Strasbourg, France. EP - 2922 TI - An influence of CD5 on the selection of CD4-lineage T cells. VL - 29 SP - 2916 KW - cd4 KW - cd5 KW - cell KW - t AU - Chan, S AU - Waltzinger, C AU - Tarakhovsky, A AU - Benoist, C AU - Mathis, D PY - 1999/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/10508266 ER -