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Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Export

Nature, Vol. 343, No. 6258. (8 February 1990), pp. 531-535.

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receptor scavenger structure

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The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.


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