Naive and memory CD4+ T cell survival controlled by clonal abundance. Export

@article{citeulike:599320, abstract = {Immunity to a plethora of microbes depends on a diverse repertoire of na\"{i}ve lymphocytes and the production of long-lived memory cells. We present evidence here that low clonal abundance in a polyclonal repertoire favors the survival and activation of na\"{i}ve CD4(+) T cells as well as the survival of their memory cell progeny. The inverse relation between clonal frequency and survival suggests that intraclonal competition could help maintain an optimally diverse repertoire of T cells and an optimal environment for the generation of long-lived memory cells.}, address = {Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. hata0006@umn.edu}, author = {Hataye, J. and Moon, J. J. and Khoruts, A. and Reilly, C. and Jenkins, M. K.}, citeulike-article-id = {599320}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1124228}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16513943}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16513943}, day = {7}, doi = {10.1126/science.1124228}, issn = {1095-9203}, journal = {Science}, keywords = {cell, survival, t}, month = {April}, number = {5770}, pages = {114--116}, posted-at = {2006-04-25 08:56:17}, priority = {3}, title = {Naive and memory CD4+ T cell survival controlled by clonal abundance.}, url = {http://dx.doi.org/10.1126/science.1124228}, volume = {312}, year = {2006} }

TY - JOUR ID - citeulike:599320 L3 - citeulike-article-id:599320 N2 - Immunity to a plethora of microbes depends on a diverse repertoire of naïve lymphocytes and the production of long-lived memory cells. We present evidence here that low clonal abundance in a polyclonal repertoire favors the survival and activation of naïve CD4(+) T cells as well as the survival of their memory cell progeny. The inverse relation between clonal frequency and survival suggests that intraclonal competition could help maintain an optimally diverse repertoire of T cells and an optimal environment for the generation of long-lived memory cells. IS - 5770 JF - Science SN - 1095-9203 AD - Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. hata0006@umn.edu EP - 116 TI - Naive and memory CD4+ T cell survival controlled by clonal abundance. VL - 312 SP - 114 KW - cell KW - survival KW - t AU - Hataye, J AU - Moon, JJ AU - Khoruts, A AU - Reilly, C AU - Jenkins, MK PY - 2006/04/07/ UR - http://dx.doi.org/10.1126/science.1124228 ER -