Ten years of protein kinase B signalling: a hard Akt to follow. Export

@article{citeulike:599322, abstract = {It is ten years since the publication of three papers describing the cloning of a new proto-oncogene serine/threonine kinase termed protein kinase B (PKB)/Akt. Key roles for this protein kinase in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration are now well established. The explosion of publications involving PKB/Akt in the past three years emphasizes the high level of current interest in this signalling molecule. This review focuses on tracing the characterization of this kinase, through the elucidation of its mechanism of regulation, to its role in regulating physiological and pathophysiological processes, to our current understanding of the biology of PKB/Akt, and prospects for the future.}, address = {Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. derek.brazil@fmi.ch}, author = {Brazil, D. P. and Hemmings, B. A.}, citeulike-article-id = {599322}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11701324}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11701324}, issn = {0968-0004}, journal = {Trends Biochem Sci}, keywords = {akt, pkb}, month = {November}, number = {11}, pages = {657--664}, posted-at = {2006-04-25 09:01:04}, priority = {5}, title = {Ten years of protein kinase B signalling: a hard Akt to follow.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11701324}, volume = {26}, year = {2001} }

TY - JOUR ID - citeulike:599322 L3 - citeulike-article-id:599322 N2 - It is ten years since the publication of three papers describing the cloning of a new proto-oncogene serine/threonine kinase termed protein kinase B (PKB)/Akt. Key roles for this protein kinase in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration are now well established. The explosion of publications involving PKB/Akt in the past three years emphasizes the high level of current interest in this signalling molecule. This review focuses on tracing the characterization of this kinase, through the elucidation of its mechanism of regulation, to its role in regulating physiological and pathophysiological processes, to our current understanding of the biology of PKB/Akt, and prospects for the future. IS - 11 JF - Trends Biochem Sci SN - 0968-0004 AD - Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. derek.brazil@fmi.ch EP - 664 TI - Ten years of protein kinase B signalling: a hard Akt to follow. VL - 26 SP - 657 KW - akt KW - pkb AU - Brazil, DP AU - Hemmings, BA PY - 2001/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/11701324 ER -