Temporal Lobe Activation Demonstrates Sex-based Differences during Passive Listening1 Export

@article{citeulike:5695215, abstract = {To evaluate potential sex differences in temporal lobe activation during the performance of a functional magnetic resonance (MR) imaging passive-listening paradigm. Twenty strongly right-handed volunteers (10 men, 10 women) underwent imaging with a 1.5-T machine by using a gradient-echo echo-planar sequence. The task consisted of passive listening to simple narrative text interleaved with same-narrative text played backward. Volumes of interest were drawn around anterior and posterior areas of activation in bilateral temporal lobes. The peak percentage of activation and the percentage of activated voxels at single-voxel significance levels of 10, 10, and 10 within each volume of interest were measured. An asymmetry index was then calculated for both anterior and posterior volumes of interest such that = ( − )/( + ), where is either the peak percentage activation or the percentage of activated voxels within the right volume of interest and is either the peak percentage activation or the percentage of activated voxels within the left volume of interest. The asymmetry indexes were compared between men and women by using a standard test. Men showed a significantly higher degree of asymmetric activation than did women in both the anterior and posterior volumes of interest by using peak percentage activation and at all single-voxel significance levels. The degree of activation asymmetry was greater by using single-voxel significance measurements, compared with peak percentage activation measures. Women demonstrate a higher degree of bilateral language representation in temporal lobe regions than do men during passive listening. These findings, combined with the variable results of prior functional MR imaging language studies of sex differences, suggest that they may be task specific.}, author = {Phillips, Micheal D. and Lowe, Mark J. and Lurito, Joseph T. and Dzemidzic, Mario and Mathews, Vincent P.}, citeulike-article-id = {5695215}, citeulike-linkout-0 = {http://radiology.rsnajnls.org/content/220/1/202.abstract}, citeulike-linkout-1 = {http://radiology.rsnajnls.org/content/220/1/202.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11425998}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11425998}, journal = {Radiology}, keywords = {gender-difference, imaging, laterality, lit-koerperbilder, sex-differences, sexual-dimorphism, temporal-lobe}, month = {July}, number = {1}, pages = {202--207}, posted-at = {2009-08-31 23:48:07}, priority = {2}, title = {Temporal Lobe Activation Demonstrates Sex-based Differences during Passive Listening1}, url = {http://radiology.rsnajnls.org/content/220/1/202.abstract}, volume = {220}, year = {2001} }

TY - JOUR ID - citeulike:5695215 L3 - citeulike-article-id:5695215 N2 - To evaluate potential sex differences in temporal lobe activation during the performance of a functional magnetic resonance (MR) imaging passive-listening paradigm. Twenty strongly right-handed volunteers (10 men, 10 women) underwent imaging with a 1.5-T machine by using a gradient-echo echo-planar sequence. The task consisted of passive listening to simple narrative text interleaved with same-narrative text played backward. Volumes of interest were drawn around anterior and posterior areas of activation in bilateral temporal lobes. The peak percentage of activation and the percentage of activated voxels at single-voxel significance levels of 10, 10, and 10 within each volume of interest were measured. An asymmetry index was then calculated for both anterior and posterior volumes of interest such that = ( − )/( + ), where is either the peak percentage activation or the percentage of activated voxels within the right volume of interest and is either the peak percentage activation or the percentage of activated voxels within the left volume of interest. The asymmetry indexes were compared between men and women by using a standard test. Men showed a significantly higher degree of asymmetric activation than did women in both the anterior and posterior volumes of interest by using peak percentage activation and at all single-voxel significance levels. The degree of activation asymmetry was greater by using single-voxel significance measurements, compared with peak percentage activation measures. Women demonstrate a higher degree of bilateral language representation in temporal lobe regions than do men during passive listening. These findings, combined with the variable results of prior functional MR imaging language studies of sex differences, suggest that they may be task specific. IS - 1 JF - Radiology EP - 207 TI - Temporal Lobe Activation Demonstrates Sex-based Differences during Passive Listening1 VL - 220 SP - 202 KW - gender-difference KW - imaging KW - laterality KW - lit-koerperbilder KW - sex-differences KW - sexual-dimorphism KW - temporal-lobe AU - Phillips, Micheal AU - Lowe, Mark AU - Lurito, Joseph AU - Dzemidzic, Mario AU - Mathews, Vincent PY - 2001/07// UR - http://radiology.rsnajnls.org/content/220/1/202.abstract ER -