Structure of a C-type mannose-binding protein complexed with an oligosaccharide Export

@article{citeulike:4519731, abstract = {C-type (Ca2+-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. The crystal structure at 1.7 \r{A} resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca2+ forms coordination bonds with the carbohydrate ligand. Carbohydrate specificity is determined by a network of coordination and hydrogen bonds that stabilizes the ternary complex of protein, Ca2+ and sugar. Two branches of the oligosaccharide crosslink neighbouring carbohydrate-recognition domains in the crystal, enabling multivalent binding to a single oligosaccharide chain to be visualized directly.}, author = {Weis, William I. and Drickamer, Kurt and Hendrickson, Wayne A.}, citeulike-article-id = {4519731}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/360127a0}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/360127a0}, day = {12}, doi = {10.1038/360127a0}, journal = {Nature}, keywords = {c-type}, month = {November}, number = {6400}, pages = {127--134}, posted-at = {2009-10-29 10:38:49}, priority = {2}, publisher = {Nature Publishing Group}, title = {Structure of a C-type mannose-binding protein complexed with an oligosaccharide}, url = {http://dx.doi.org/10.1038/360127a0}, volume = {360}, year = {1992} }

TY - JOUR ID - citeulike:4519731 L3 - citeulike-article-id:4519731 N2 - C-type (Ca2+-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. The crystal structure at 1.7 Å resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca2+ forms coordination bonds with the carbohydrate ligand. Carbohydrate specificity is determined by a network of coordination and hydrogen bonds that stabilizes the ternary complex of protein, Ca2+ and sugar. Two branches of the oligosaccharide crosslink neighbouring carbohydrate-recognition domains in the crystal, enabling multivalent binding to a single oligosaccharide chain to be visualized directly. IS - 6400 JF - Nature EP - 134 TI - Structure of a C-type mannose-binding protein complexed with an oligosaccharide PB - Nature Publishing Group VL - 360 SP - 127 KW - c-type AU - Weis, William AU - Drickamer, Kurt AU - Hendrickson, Wayne PY - 1992/11/12/ UR - http://dx.doi.org/10.1038/360127a0 ER -