Identification and characterization of small RNAs involved in RNA silencing. Export

@article{citeulike:848244, abstract = {Double-stranded RNA (dsRNA) is a potent trigger of sequence-specific gene silencing mechanisms known as RNA silencing or RNA interference. The recognition of the target sequences is mediated by ribonucleoprotein complexes that contain 21- to 28-nucleotide (nt) guide RNAs derived from processing of the trigger dsRNA. Here, we review the experimental and bioinformatic approaches that were used to identify and characterize these small RNAs isolated from cells and tissues. The identification and characterization of small RNAs and their expression patterns is important for elucidating gene regulatory networks.}, author = {Aravin, A. and Tuschl, T.}, booktitle = {RNAi: Mechanisms, Biology and Applications}, citeulike-article-id = {848244}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.febslet.2005.08.009}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16153643}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16153643}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6T36-4GX1P4J-1/2/412df1a799bce43450487e39cdfb1585}, day = {31}, doi = {10.1016/j.febslet.2005.08.009}, issn = {0014-5793}, journal = {FEBS letters}, keywords = {rnai}, month = {October}, number = {26}, pages = {5830--5840}, posted-at = {2008-05-09 14:50:05}, priority = {2}, title = {Identification and characterization of small RNAs involved in RNA silencing.}, url = {http://dx.doi.org/10.1016/j.febslet.2005.08.009}, volume = {579}, year = {2005} }

TY - JOUR ID - citeulike:848244 L3 - citeulike-article-id:848244 N2 - Double-stranded RNA (dsRNA) is a potent trigger of sequence-specific gene silencing mechanisms known as RNA silencing or RNA interference. The recognition of the target sequences is mediated by ribonucleoprotein complexes that contain 21- to 28-nucleotide (nt) guide RNAs derived from processing of the trigger dsRNA. Here, we review the experimental and bioinformatic approaches that were used to identify and characterize these small RNAs isolated from cells and tissues. The identification and characterization of small RNAs and their expression patterns is important for elucidating gene regulatory networks. IS - 26 JF - FEBS letters SN - 0014-5793 EP - 5840 TI - Identification and characterization of small RNAs involved in RNA silencing. VL - 579 T2 - RNAi: Mechanisms, Biology and Applications SP - 5830 KW - rnai AU - Aravin, A AU - Tuschl, T PY - 2005/10/31/ UR - http://dx.doi.org/10.1016/j.febslet.2005.08.009 ER -