Nucleosome positioning and gene regulation: advances through genomics Export

@article{Jiang2009, abstract = {Knowing the precise locations of nucleosomes in a genome is key to understanding how genes are regulated. Recent 'next generation' ChIP–chip and ChIP–Seq technologies have accelerated our understanding of the basic principles of chromatin organization. Here we discuss what high-resolution genome-wide maps of nucleosome positions have taught us about how nucleosome positioning demarcates promoter regions and transcriptional start sites, and how the composition and structure of promoter nucleosomes facilitate or inhibit transcription. A detailed picture is starting to emerge of how diverse factors, including underlying DNA sequences and chromatin remodelling complexes, influence nucleosome positioning.}, author = {Jiang, Cizhong and Pugh, B. Franklin}, citeulike-article-id = {4042288}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2522}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2522}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19204718}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19204718}, day = {01}, doi = {10.1038/nrg2522}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {chip-seq, nucleosome, review}, month = {March}, number = {3}, pages = {161--172}, posted-at = {2009-04-22 16:43:51}, priority = {2}, publisher = {Nature Publishing Group}, title = {Nucleosome positioning and gene regulation: advances through genomics}, url = {http://dx.doi.org/10.1038/nrg2522}, volume = {10}, year = {2009} }

TY - JOUR ID - Jiang2009 L3 - citeulike-article-id:4042288 N2 - Knowing the precise locations of nucleosomes in a genome is key to understanding how genes are regulated. Recent 'next generation' ChIP–chip and ChIP–Seq technologies have accelerated our understanding of the basic principles of chromatin organization. Here we discuss what high-resolution genome-wide maps of nucleosome positions have taught us about how nucleosome positioning demarcates promoter regions and transcriptional start sites, and how the composition and structure of promoter nucleosomes facilitate or inhibit transcription. A detailed picture is starting to emerge of how diverse factors, including underlying DNA sequences and chromatin remodelling complexes, influence nucleosome positioning. IS - 3 JF - Nature Reviews Genetics SN - 1471-0056 EP - 172 TI - Nucleosome positioning and gene regulation: advances through genomics PB - Nature Publishing Group VL - 10 SP - 161 KW - chip-seq KW - nucleosome KW - review AU - Jiang, Cizhong AU - Pugh, Franklin PY - 2009/03/01/ UR - http://dx.doi.org/10.1038/nrg2522 ER -