The angiotensin-converting enzyme gene family: genomics and pharmacology. Export

@article{citeulike:264024, abstract = {Modulation of the renin-angiotensin system (RAS), and particularly inhibition of angiotensin-converting enzyme (ACE), a zinc metallopeptidase, has long been a prime strategy in the treatment of hypertension. However, other angiotensin metabolites are gaining in importance as our understanding of the RAS increases. Recently, genomic approaches have identified the first human homologue of ACE, termed ACEH (or ACE2). ACEH differs in specificity and physiological roles from ACE, which opens a potential new area for discovery biology. The gene that encodes collectrin, a homologue of ACEH, is upregulated in response to renal injury. Collectrin lacks a catalytic domain, which indicates that there is more to ACE-like function than simple peptide hydrolysis.}, address = {Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK. a.j.turner@leeds.ac.uk}, author = {Turner, A. J. and Hooper, N. M.}, citeulike-article-id = {264024}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11931993}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11931993}, issn = {0165-6147}, journal = {Trends Pharmacol Sci}, keywords = {ace, ace2}, month = {April}, number = {4}, pages = {177--183}, posted-at = {2005-07-25 08:22:44}, priority = {2}, title = {The angiotensin-converting enzyme gene family: genomics and pharmacology.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11931993}, volume = {23}, year = {2002} }

TY - JOUR ID - citeulike:264024 L3 - citeulike-article-id:264024 N2 - Modulation of the renin-angiotensin system (RAS), and particularly inhibition of angiotensin-converting enzyme (ACE), a zinc metallopeptidase, has long been a prime strategy in the treatment of hypertension. However, other angiotensin metabolites are gaining in importance as our understanding of the RAS increases. Recently, genomic approaches have identified the first human homologue of ACE, termed ACEH (or ACE2). ACEH differs in specificity and physiological roles from ACE, which opens a potential new area for discovery biology. The gene that encodes collectrin, a homologue of ACEH, is upregulated in response to renal injury. Collectrin lacks a catalytic domain, which indicates that there is more to ACE-like function than simple peptide hydrolysis. IS - 4 JF - Trends Pharmacol Sci SN - 0165-6147 AD - Proteolysis Research Group, School of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK. a.j.turner@leeds.ac.uk EP - 183 TI - The angiotensin-converting enzyme gene family: genomics and pharmacology. VL - 23 SP - 177 KW - ace KW - ace2 AU - Turner, AJ AU - Hooper, NM PY - 2002/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/11931993 ER -