The h-channel: A potential channelopathy in epilepsy? Export

@article{citeulike:267336, abstract = {Ion channelopathy is a proven cause of inherited human epilepsy, and may play a role in acquired epileptic syndromes as well. Of the many ion channel causes of epilepsy, the h-hannel is a potential new addition. H-channels are voltage-gated ion channels with unique biophysical properties. The h-channel exerts a significant modulatory influence on neuronal excitability, and is a target of antiepileptic drugs. Further, its activity is influenced by seizures, raising the question of whether it may play a role in epileptogenesis as well. This review summarizes the evidence for the contribution of h-channels to seizures and epilepsy, and outlines hypotheses concerning the existence of an "h-channelopathy" in human epilepsy.}, address = {Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, WA, USA.}, author = {Poolos, N. P.}, citeulike-article-id = {267336}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.yebeh.2005.04.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15961349}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15961349}, doi = {10.1016/j.yebeh.2005.04.007}, issn = {1525-5050}, journal = {Epilepsy Behav}, keywords = {epilepsy, hcn}, month = {August}, number = {1}, pages = {51--56}, posted-at = {2005-09-17 15:25:21}, priority = {2}, title = {The h-channel: A potential channelopathy in epilepsy?}, url = {http://dx.doi.org/10.1016/j.yebeh.2005.04.007}, volume = {7}, year = {2005} }

TY - JOUR ID - citeulike:267336 L3 - citeulike-article-id:267336 N2 - Ion channelopathy is a proven cause of inherited human epilepsy, and may play a role in acquired epileptic syndromes as well. Of the many ion channel causes of epilepsy, the h-hannel is a potential new addition. H-channels are voltage-gated ion channels with unique biophysical properties. The h-channel exerts a significant modulatory influence on neuronal excitability, and is a target of antiepileptic drugs. Further, its activity is influenced by seizures, raising the question of whether it may play a role in epileptogenesis as well. This review summarizes the evidence for the contribution of h-channels to seizures and epilepsy, and outlines hypotheses concerning the existence of an "h-channelopathy" in human epilepsy. IS - 1 JF - Epilepsy Behav SN - 1525-5050 AD - Department of Neurology and Regional Epilepsy Center, University of Washington, Seattle, WA, USA. EP - 56 TI - The h-channel: A potential channelopathy in epilepsy? VL - 7 SP - 51 KW - epilepsy KW - hcn AU - Poolos, NP PY - 2005/08// UR - http://dx.doi.org/10.1016/j.yebeh.2005.04.007 ER -