Cerebral blood flow and the hyperdynamic circulation of rats after portacaval anastomosis. Export

@article{citeulike:338449, abstract = {Both increased and decreased values of cerebral blood flow have been reported in liver disease. Furthermore, the relation between the cerebral circulation and the generalized hemodynamic disturbance seen in chronic liver disease with portal-systemic shunting has not been fully characterized. We studied this problem in a well defined model of the hyperdynamic circulation, the rat after portacaval anastomosis (PCA). Using the radioactive microsphere technique, cardiac output and regional blood flows were measured; regional vascular resistances were then calculated. While the fraction of cardiac output perfusing the splanchnic bed was significantly increased, the corresponding brain fraction was reduced. Blood flow to the cerebral hemispheres and midbrain was significantly decreased. Arterial vasodilatation was demonstrated by the fall in arterial pressure, systemic vascular resistance as well as splanchnic and renal resistances; cerebrovascular resistance, however, was unchanged. No relation between values of arterial pressure and cerebral blood flow was seen, making a failure of cerebrovascular autoregulation unlikely. The decrease in hemispheric and midbrain perfusion without changes in vascular resistance suggests that a drop in blood flow is appropriately coupled to a reduction in brain metabolism. The cerebral circulation does not participate in the hyperdynamic state that is seen in this model.}, address = {Department of Medicine, Lakeside VA Medical Center, Chicago, IL 60611.}, author = {Srivastava, A. and Gottstein, J. and Blei, A. T.}, citeulike-article-id = {338449}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8445215}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8445215}, issn = {0168-8278}, journal = {J Hepatol}, keywords = {cardiac\_output, cerebral, hemodynamics}, month = {January}, number = {1}, pages = {15--19}, posted-at = {2005-10-01 18:50:31}, priority = {0}, title = {Cerebral blood flow and the hyperdynamic circulation of rats after portacaval anastomosis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8445215}, volume = {17}, year = {1993} }

TY - JOUR ID - citeulike:338449 L3 - citeulike-article-id:338449 N2 - Both increased and decreased values of cerebral blood flow have been reported in liver disease. Furthermore, the relation between the cerebral circulation and the generalized hemodynamic disturbance seen in chronic liver disease with portal-systemic shunting has not been fully characterized. We studied this problem in a well defined model of the hyperdynamic circulation, the rat after portacaval anastomosis (PCA). Using the radioactive microsphere technique, cardiac output and regional blood flows were measured; regional vascular resistances were then calculated. While the fraction of cardiac output perfusing the splanchnic bed was significantly increased, the corresponding brain fraction was reduced. Blood flow to the cerebral hemispheres and midbrain was significantly decreased. Arterial vasodilatation was demonstrated by the fall in arterial pressure, systemic vascular resistance as well as splanchnic and renal resistances; cerebrovascular resistance, however, was unchanged. No relation between values of arterial pressure and cerebral blood flow was seen, making a failure of cerebrovascular autoregulation unlikely. The decrease in hemispheric and midbrain perfusion without changes in vascular resistance suggests that a drop in blood flow is appropriately coupled to a reduction in brain metabolism. The cerebral circulation does not participate in the hyperdynamic state that is seen in this model. IS - 1 JF - J Hepatol SN - 0168-8278 AD - Department of Medicine, Lakeside VA Medical Center, Chicago, IL 60611. EP - 19 TI - Cerebral blood flow and the hyperdynamic circulation of rats after portacaval anastomosis. VL - 17 SP - 15 KW - cardiac_output KW - cerebral KW - hemodynamics AU - Srivastava, A AU - Gottstein, J AU - Blei, AT PY - 1993/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/8445215 ER -