Dextrous artificial hand design and manipulation is an active research topic. A very interesting practical application is the field of upper limb prosthetics. This paper presents the mechanical design and manipulation aspects of the MANUS-HAND project to develop a multifunctional upper limb prosthesis. The kinematics of our design makes use of the so-called underactuated principle and leads to an innovative design that triples the performance of currently existing commercial hand prosthesis. In addition, the thumb design allows its positioning both in flexion and opposition. As a consequence, up to four grasping modes (cylindrical, precision, hook and lateral) are available with just two actuators.