Helminth infections: the great neglected tropical diseases. Export

@article{citeulike:2744946, abstract = {Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.}, address = {Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC, USA. Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Bill and Melinda Gates Foundation, Seattle, Washington, USA.}, author = {Hotez, Peter J J. and Brindley, Paul J J. and Bethony, Jeffrey M M. and King, Charles H H. and Pearce, Edward J J. and Jacobson, Julie}, citeulike-article-id = {2744946}, citeulike-linkout-0 = {http://dx.doi.org/10.1172/JCI34261}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18382743}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18382743}, day = {1}, doi = {10.1172/JCI34261}, issn = {0021-9738}, journal = {The Journal of clinical investigation}, keywords = {helminth, infections, review, tropicaldisease}, month = {April}, number = {4}, pages = {1311--1321}, posted-at = {2008-06-20 20:40:00}, priority = {4}, title = {Helminth infections: the great neglected tropical diseases.}, url = {http://dx.doi.org/10.1172/JCI34261}, volume = {118}, year = {2008} }

TY - JOUR ID - citeulike:2744946 L3 - citeulike-article-id:2744946 N2 - Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans. IS - 4 JF - The Journal of clinical investigation SN - 0021-9738 AD - Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC, USA. Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Bill and Melinda Gates Foundation, Seattle, Washington, USA. EP - 1321 TI - Helminth infections: the great neglected tropical diseases. VL - 118 SP - 1311 KW - helminth KW - infections KW - review KW - tropicaldisease AU - Hotez, Peter J AU - Brindley, Paul J AU - Bethony, Jeffrey M AU - King, Charles H AU - Pearce, Edward J AU - Jacobson, Julie PY - 2008/04/01/ UR - http://dx.doi.org/10.1172/JCI34261 ER -