Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. Export

@article{citeulike:3277553, abstract = {How does the nervous system encode environmental stimuli as sensory experiences? Both the type (visual, olfactory, gustatory, mechanical or auditory) and the quality of a stimulus (spatial position, intensity or frequency) are represented as a neural code. Here we undertake a genetic analysis of sensory modality coding in Caenorhabditis elegans. The ASH sensory neurons respond to two distinct sensory stimuli (nose touch and osmotic stimuli). A mutation in the glr-1 (glutamate receptor) gene eliminates the response to nose touch but not to osmotic repellents. The predicted GLR-1 protein is roughly 40\% identical to mammalian AMPA-class glutamate receptor (GluR) subunits. Analysis of glr-1 expression and genetic mosaics indicates that GLR-1 receptors act in synaptic targets of the ASH neurons. We propose that discrimination between the ASH sensory modalities arises from differential release of ASH neurotransmitters in response to different stimuli.}, author = {Hart, A. C. and Sims, S. and Kaplan, J. M.}, citeulike-article-id = {3277553}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7477294}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7477294}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00002309}, journal = {Nature}, keywords = {article, c06e14, c\_elegans, caenorhabditis\_elegans, caenorhabditis\_elegans\_genetics, caenorhabditis\_elegans\_physiology, celegans, chimera, elegans, gene\_expression, glr-1, membrane\_proteins\_physiology, movement, mutation, nematode, nerve\_tissue\_proteins\_physiology, neurons\_afferent\_physiology, neurons\_physiology, receptors\_glutamate\_genetics, receptors\_glutamate\_physiology, synapses\_physiology, touch, wormbase}, pages = {82--85}, posted-at = {2008-09-17 00:52:44}, priority = {3}, title = {Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7477294}, volume = {378}, year = {1995} }

TY - JOUR ID - citeulike:3277553 L3 - citeulike-article-id:3277553 N2 - How does the nervous system encode environmental stimuli as sensory experiences? Both the type (visual, olfactory, gustatory, mechanical or auditory) and the quality of a stimulus (spatial position, intensity or frequency) are represented as a neural code. Here we undertake a genetic analysis of sensory modality coding in Caenorhabditis elegans. The ASH sensory neurons respond to two distinct sensory stimuli (nose touch and osmotic stimuli). A mutation in the glr-1 (glutamate receptor) gene eliminates the response to nose touch but not to osmotic repellents. The predicted GLR-1 protein is roughly 40% identical to mammalian AMPA-class glutamate receptor (GluR) subunits. Analysis of glr-1 expression and genetic mosaics indicates that GLR-1 receptors act in synaptic targets of the ASH neurons. We propose that discrimination between the ASH sensory modalities arises from differential release of ASH neurotransmitters in response to different stimuli. JF - Nature EP - 85 TI - Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor. VL - 378 SP - 82 KW - article KW - c06e14 KW - c_elegans KW - caenorhabditis_elegans KW - caenorhabditis_elegans_genetics KW - caenorhabditis_elegans_physiology KW - celegans KW - chimera KW - elegans KW - gene_expression KW - glr-1 KW - membrane_proteins_physiology KW - movement KW - mutation KW - nematode KW - nerve_tissue_proteins_physiology KW - neurons_afferent_physiology KW - neurons_physiology KW - receptors_glutamate_genetics KW - receptors_glutamate_physiology KW - synapses_physiology KW - touch KW - wormbase AU - Hart, AC AU - Sims, S AU - Kaplan, JM PY - 1995/// UR - http://view.ncbi.nlm.nih.gov/pubmed/7477294 ER -