Ins/IGF-1 signalling: effects of the germline and of food sensing on metabolism and stress defence Export

@inproceedings{citeulike:3319531, abstract = {The evolutionary conserved Ins/IGF-1 pathway regulates the development, ageing rate, metabolism and stress defence of C. elegans. To investigate the role of metabolic shifts in the determination of life span, we measured several metabolic parameters of the long-lived daf-2, age-1 and aap-1 mutants. We found that these mutants have a smaller body size, an altered CR ratio (a measure of metabolic efficiency), a much higher ATP content and reductive capacity, and elevated activities of SOD and catalase. The activity of the Ins/IGF-1 pathway is regulated by food sensing and by signals from the reproductive system. We thus measured the same metabolic parameters in mutants lacking germ cells and in mutants with limited food sensing capacities. We found little differences in the metabolism of wild type and food sensing mutants, but saw that most metabolic alterations seen in Ins/IGF-1 mutants are also observed in mutants lacking a developed germline. We thus hypothesize that the germline is the major regulator of Ins/IGF-1 signaling, or that the Ins/IGF-1 pathway regulates germline development, causing metabolic alterations.}, author = {Houthoofd, Koen and Braeckman, Bart and Lenaerts, Isabelle and Brys, Kristel and Matthijssens, Filip and Hoogewijs, David and De Vreese, Annemie and Van Eygen, Sylvie and Vanfleteren, Jacques}, citeulike-article-id = {3319531}, citeulike-linkout-0 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00025914}, journal = {International Worm Meeting}, keywords = {aap-1, age-1, b03348, c\_elegans, caenorhabditis\_elegans, celegans, daf-2, elegans, meeting\_abstract, nematode, wormbase, y110a7a10, y55d5a5}, posted-at = {2008-09-23 03:54:40}, priority = {3}, title = {Ins/IGF-1 signalling: effects of the germline and of food sensing on metabolism and stress defence}, url = {http://www.wormbase.org/db/misc/paper?name=WBPaper00025914}, year = {2005} }

TY - CONF ID - citeulike:3319531 L3 - citeulike-article-id:3319531 N2 - The evolutionary conserved Ins/IGF-1 pathway regulates the development, ageing rate, metabolism and stress defence of C. elegans. To investigate the role of metabolic shifts in the determination of life span, we measured several metabolic parameters of the long-lived daf-2, age-1 and aap-1 mutants. We found that these mutants have a smaller body size, an altered CR ratio (a measure of metabolic efficiency), a much higher ATP content and reductive capacity, and elevated activities of SOD and catalase. The activity of the Ins/IGF-1 pathway is regulated by food sensing and by signals from the reproductive system. We thus measured the same metabolic parameters in mutants lacking germ cells and in mutants with limited food sensing capacities. We found little differences in the metabolism of wild type and food sensing mutants, but saw that most metabolic alterations seen in Ins/IGF-1 mutants are also observed in mutants lacking a developed germline. We thus hypothesize that the germline is the major regulator of Ins/IGF-1 signaling, or that the Ins/IGF-1 pathway regulates germline development, causing metabolic alterations. JF - International Worm Meeting TI - Ins/IGF-1 signalling: effects of the germline and of food sensing on metabolism and stress defence KW - aap-1 KW - age-1 KW - b03348 KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - daf-2 KW - elegans KW - meeting_abstract KW - nematode KW - wormbase KW - y110a7a10 KW - y55d5a5 AU - Houthoofd, Koen AU - Braeckman, Bart AU - Lenaerts, Isabelle AU - Brys, Kristel AU - Matthijssens, Filip AU - Hoogewijs, David AU - De Vreese, Annemie AU - Van Eygen, Sylvie AU - Vanfleteren, Jacques PY - 2005/// UR - http://www.wormbase.org/db/misc/paper?name=WBPaper00025914 ER -