Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in C. elegans Export

@inproceedings{citeulike:3337308, abstract = {"Appropriate clearance of apoptotic cell (cell corpse) is an important step of programmed cell death. Although genetic and biochemical studies have identified several genes that regulate the engulfment of cell corpse, how cell corpse is degraded after internalized in engulfing cell remains largely elusive. Here we show that vps-18, the C. elegans homologue of yeast Vps18p, is critical to cell corpse degradation. VPS-18 is expressed and functions in engulfing cells. Deletion of vps-18 leads to significant accumulation of cell corpses that are not degraded properly. Furthermore, vps-18 mutation causes strong defects in the biogenesis of early endosomes, late endosomes and lysosomes, thus affecting endosome-lysosome trafficking and lysosomal protein degradation. Importantly, we demonstrate that the internalized cell corpse is unable to fuse with the aberrant lysosomes in vps-18 mutants. Our findings thus provide direct evidence for the important role of endosomal/lysosomal degradation in proper clearance of apoptotic cells during programmed cell death."}, author = {Xiao, Hui and Chen, Didi and Fang, Zhou and Xu, Jing and Sun, Xiaojuan and Yang, Chonglin}, citeulike-article-id = {3337308}, citeulike-linkout-0 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031798}, keywords = {c\_elegans, caenorhabditis\_elegans, celegans, elegans, meeting\_abstract, nematode, wormbase}, posted-at = {2008-09-25 17:26:19}, priority = {3}, title = {Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in C. elegans}, url = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031798} }

TY - CONF ID - citeulike:3337308 L3 - citeulike-article-id:3337308 N2 - "Appropriate clearance of apoptotic cell (cell corpse) is an important step of programmed cell death. Although genetic and biochemical studies have identified several genes that regulate the engulfment of cell corpse, how cell corpse is degraded after internalized in engulfing cell remains largely elusive. Here we show that vps-18, the C. elegans homologue of yeast Vps18p, is critical to cell corpse degradation. VPS-18 is expressed and functions in engulfing cells. Deletion of vps-18 leads to significant accumulation of cell corpses that are not degraded properly. Furthermore, vps-18 mutation causes strong defects in the biogenesis of early endosomes, late endosomes and lysosomes, thus affecting endosome-lysosome trafficking and lysosomal protein degradation. Importantly, we demonstrate that the internalized cell corpse is unable to fuse with the aberrant lysosomes in vps-18 mutants. Our findings thus provide direct evidence for the important role of endosomal/lysosomal degradation in proper clearance of apoptotic cells during programmed cell death." TI - Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in C. elegans KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - meeting_abstract KW - nematode KW - wormbase AU - Xiao, Hui AU - Chen, Didi AU - Fang, Zhou AU - Xu, Jing AU - Sun, Xiaojuan AU - Yang, Chonglin UR - http://www.wormbase.org/db/misc/paper?name=WBPaper00031798 ER -