The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions. Export

@article{citeulike:3337703, abstract = {We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the expression level of two nicotinic acetylcholine receptor (nAChR) subunits (UNC-29 and UNC-63), thereby altering muscle sensitivity to acetylcholine (ACh). miR-1 also regulates the muscle transcription factor MEF-2, which results in altered presynaptic ACh secretion, suggesting that MEF-2 activity in muscles controls a retrograde signal. The effect of the MEF-2-dependent retrograde signal on secretion is mediated by the synaptic vesicle protein RAB-3. Finally, acute activation of levamisole-sensitive nAChRs stimulates MEF-2-dependent transcriptional responses and induces the MEF-2-dependent retrograde signal. We propose that miR-1 refines synaptic function by coupling changes in muscle activity to changes in presynaptic function.}, author = {Simon, D. J. and Madison, J. M. and Conery, A. L. and Thompson-Peer, K. L. and Soskis, M. and Ruvkun, G. B. and Kaplan, J. M. and Kim, J. K.}, citeulike-article-id = {3337703}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2008.04.035}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18510933}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18510933}, citeulike-linkout-3 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031913}, doi = {10.1016/j.cell.2008.04.035}, journal = {Cell}, keywords = {article, c18a36, c24a118, c\_elegans, caenorhabditis\_elegans, celegans, elegans, f21f35, f35d25, frm-4, mef-2, mir-1, nematode, rab-3, snb-1, syd-1, t08g115, t09b411, t10h94, unc-29, unc-38, unc-63, w10d51, wormbase, y110a7a3}, pages = {903--915}, posted-at = {2008-09-25 17:57:49}, priority = {3}, title = {The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions.}, url = {http://dx.doi.org/10.1016/j.cell.2008.04.035}, volume = {133}, year = {2008} }

TY - JOUR ID - citeulike:3337703 L3 - citeulike-article-id:3337703 N2 - We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the expression level of two nicotinic acetylcholine receptor (nAChR) subunits (UNC-29 and UNC-63), thereby altering muscle sensitivity to acetylcholine (ACh). miR-1 also regulates the muscle transcription factor MEF-2, which results in altered presynaptic ACh secretion, suggesting that MEF-2 activity in muscles controls a retrograde signal. The effect of the MEF-2-dependent retrograde signal on secretion is mediated by the synaptic vesicle protein RAB-3. Finally, acute activation of levamisole-sensitive nAChRs stimulates MEF-2-dependent transcriptional responses and induces the MEF-2-dependent retrograde signal. We propose that miR-1 refines synaptic function by coupling changes in muscle activity to changes in presynaptic function. JF - Cell EP - 915 TI - The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions. VL - 133 SP - 903 KW - article KW - c18a36 KW - c24a118 KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - f21f35 KW - f35d25 KW - frm-4 KW - mef-2 KW - mir-1 KW - nematode KW - rab-3 KW - snb-1 KW - syd-1 KW - t08g115 KW - t09b411 KW - t10h94 KW - unc-29 KW - unc-38 KW - unc-63 KW - w10d51 KW - wormbase KW - y110a7a3 AU - Simon, DJ AU - Madison, JM AU - Conery, AL AU - Thompson-Peer, KL AU - Soskis, M AU - Ruvkun, GB AU - Kaplan, JM AU - Kim, JK PY - 2008/// UR - http://dx.doi.org/10.1016/j.cell.2008.04.035 ER -