Inhibition of Developmental Processes by Flavone in Caenorhabditis elegans and its Application to the Pinewood Nematode, Bursaphelenchus xylophilus. Export

@article{citeulike:3337796, abstract = {Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus. LD50 values were approximately 100 muM for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.}, author = {Lee, Y. U. and Kawasaki, I. and Lim, Y. and Oh, W. S. and Paik, Y. K. and Shim, Y. H.}, citeulike-article-id = {3337796}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18596412}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18596412}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00031991}, journal = {Mol Cells}, keywords = {c\_elegans, caenorhabditis\_elegans, celegans, elegans, nematode, other, wormbase}, posted-at = {2008-09-25 18:18:19}, priority = {3}, title = {Inhibition of Developmental Processes by Flavone in Caenorhabditis elegans and its Application to the Pinewood Nematode, Bursaphelenchus xylophilus.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18596412}, volume = {26}, year = {2008} }

TY - JOUR ID - citeulike:3337796 L3 - citeulike-article-id:3337796 N2 - Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus. LD50 values were approximately 100 muM for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus. JF - Mol Cells TI - Inhibition of Developmental Processes by Flavone in Caenorhabditis elegans and its Application to the Pinewood Nematode, Bursaphelenchus xylophilus. VL - 26 KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - nematode KW - other KW - wormbase AU - Lee, YU AU - Kawasaki, I AU - Lim, Y AU - Oh, WS AU - Paik, YK AU - Shim, YH PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18596412 ER -