The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues. Export

@article{citeulike:3337815, abstract = {The F-spondin family of extracellular matrix proteins has been implicated in axon outgrowth, fasciculation and neuronal cell migration, as well as in the differentiation and proliferation of non-neuronal cells. In screens for mutants defective in C. elegans embryonic morphogenesis, we identified SPON-1, the only C. elegans member of the spondin family. SPON-1 is synthesized in body muscles and localizes to integrin-containing structures on body muscles and to other basement membranes. SPON-1 maintains strong attachments of muscles to epidermis; in the absence of SPON-1, muscles progressively detach from the epidermis, causing defective epidermal elongation. In animals with reduced integrin function, SPON-1 becomes dose dependent, suggesting that SPON-1 and integrins function in concert to promote the attachment of muscles to the basement membrane. Although spon-1 mutants display largely normal neurite outgrowth, spon-1 synergizes with outgrowth defective mutants, revealing a cryptic role for SPON-1 in axon extension. In motoneurons, SPON-1 acts in axon guidance and fasciculation, whereas in interneurons SPON-1 maintains process position. Our results show that a spondin maintains cell-matrix adhesion in multiple tissues.}, author = {Woo, W. M. and Berry, E. C. and Hudson, M. L. and Swale, R. E. and Goncharov, A. and Chisholm, A. D.}, citeulike-article-id = {3337815}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18614580}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18614580}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00032007}, journal = {Development}, keywords = {c\_elegans, caenorhabditis\_elegans, celegans, elegans, f10e74, nematode, other, spon-1, wormbase}, posted-at = {2008-09-25 18:22:57}, priority = {3}, title = {The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18614580}, year = {2008} }

TY - JOUR ID - citeulike:3337815 L3 - citeulike-article-id:3337815 N2 - The F-spondin family of extracellular matrix proteins has been implicated in axon outgrowth, fasciculation and neuronal cell migration, as well as in the differentiation and proliferation of non-neuronal cells. In screens for mutants defective in C. elegans embryonic morphogenesis, we identified SPON-1, the only C. elegans member of the spondin family. SPON-1 is synthesized in body muscles and localizes to integrin-containing structures on body muscles and to other basement membranes. SPON-1 maintains strong attachments of muscles to epidermis; in the absence of SPON-1, muscles progressively detach from the epidermis, causing defective epidermal elongation. In animals with reduced integrin function, SPON-1 becomes dose dependent, suggesting that SPON-1 and integrins function in concert to promote the attachment of muscles to the basement membrane. Although spon-1 mutants display largely normal neurite outgrowth, spon-1 synergizes with outgrowth defective mutants, revealing a cryptic role for SPON-1 in axon extension. In motoneurons, SPON-1 acts in axon guidance and fasciculation, whereas in interneurons SPON-1 maintains process position. Our results show that a spondin maintains cell-matrix adhesion in multiple tissues. JF - Development TI - The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues. KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - f10e74 KW - nematode KW - other KW - spon-1 KW - wormbase AU - Woo, WM AU - Berry, EC AU - Hudson, ML AU - Swale, RE AU - Goncharov, A AU - Chisholm, AD PY - 2008/// UR - http://view.ncbi.nlm.nih.gov/pubmed/18614580 ER -