Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). Export

@article{citeulike:3337853, abstract = {The ETV6 gene (also known as TEL) is the main target of chromosomal translocations affecting chromosome band 12p13. The rearrangements fuse ETV6 to a wide variety of partner genes in both myeloid and lymphoid malignancies. We report here 4 new cases of acute myeloid leukemia (AML) with very immature myeloblasts (French-American-British [FAB]-M0) and with a t(4;12)(q11-q12;p13). In all cases, ETV6 was found recombined to a new gene, homologous to the mouse Brx gene. The gene was named BTL (Brx-like Translocated in Leukemia). Reverse transcriptase-polymerase chain reaction (RT-PCR) experiments indicate that the expression of the BTL-ETV6 transcript, but not of the reciprocal ETV6-BTL transcript, is a common finding in these leukemias. In contrast to the majority of other ETV6 fusions, both the complete helix-loop-helix (HLH) and ETS DNA binding domains of ETV6 are present in the predicted BTL-ETV6 fusion protein, and the chimeric gene is transcribed from the BTL promoter.}, author = {Cools, J. and Bilhou-Nabera, C. and Wlodarska, I. and Cabrol, C. and Talmant, P. and Bernard, P. and Hagemeijer, A. and Marynen, P.}, citeulike-article-id = {3337853}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10477709}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10477709}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00032046}, journal = {Blood}, keywords = {c\_elegans, caenorhabditis\_elegans, celegans, elegans, nematode, other, wormbase}, pages = {1820--1824}, posted-at = {2008-09-25 18:32:13}, priority = {3}, title = {Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10477709}, volume = {94}, year = {1999} }

TY - JOUR ID - citeulike:3337853 L3 - citeulike-article-id:3337853 N2 - The ETV6 gene (also known as TEL) is the main target of chromosomal translocations affecting chromosome band 12p13. The rearrangements fuse ETV6 to a wide variety of partner genes in both myeloid and lymphoid malignancies. We report here 4 new cases of acute myeloid leukemia (AML) with very immature myeloblasts (French-American-British [FAB]-M0) and with a t(4;12)(q11-q12;p13). In all cases, ETV6 was found recombined to a new gene, homologous to the mouse Brx gene. The gene was named BTL (Brx-like Translocated in Leukemia). Reverse transcriptase-polymerase chain reaction (RT-PCR) experiments indicate that the expression of the BTL-ETV6 transcript, but not of the reciprocal ETV6-BTL transcript, is a common finding in these leukemias. In contrast to the majority of other ETV6 fusions, both the complete helix-loop-helix (HLH) and ETS DNA binding domains of ETV6 are present in the predicted BTL-ETV6 fusion protein, and the chimeric gene is transcribed from the BTL promoter. JF - Blood EP - 1824 TI - Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). VL - 94 SP - 1820 KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - nematode KW - other KW - wormbase AU - Cools, J AU - Bilhou-Nabera, C AU - Wlodarska, I AU - Cabrol, C AU - Talmant, P AU - Bernard, P AU - Hagemeijer, A AU - Marynen, P PY - 1999/// UR - http://view.ncbi.nlm.nih.gov/pubmed/10477709 ER -