A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. Export

@article{citeulike:3337854, abstract = {We recently cloned the CHIC2 gene (previously BTL) by virtue of its involvement in a chromosomal translocation t(4;12)(q11;p13) occurring in acute myeloid leukemias. In this study we show that CHIC2 is a member of a highly conserved family of proteins characterized by the presence of a striking cysteine-rich hydrophobic (CHIC) motif. Our data illustrate that cysteines in this central CHIC motif are palmitoylated and that CHIC2 is associated with vesicular structures and the plasma membrane. The CHIC proteins thus resemble the cysteine string proteins, which function in regulated exocytosis.}, author = {Cools, J. and Mentens, N. and Marynen, P.}, citeulike-article-id = {3337854}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11257495}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11257495}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00032047}, journal = {FEBS Lett}, keywords = {article, c\_elegans, caenorhabditis\_elegans, celegans, elegans, nematode, wormbase}, pages = {204--209}, posted-at = {2008-09-25 18:32:25}, priority = {3}, title = {A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11257495}, volume = {492}, year = {2001} }

TY - JOUR ID - citeulike:3337854 L3 - citeulike-article-id:3337854 N2 - We recently cloned the CHIC2 gene (previously BTL) by virtue of its involvement in a chromosomal translocation t(4;12)(q11;p13) occurring in acute myeloid leukemias. In this study we show that CHIC2 is a member of a highly conserved family of proteins characterized by the presence of a striking cysteine-rich hydrophobic (CHIC) motif. Our data illustrate that cysteines in this central CHIC motif are palmitoylated and that CHIC2 is associated with vesicular structures and the plasma membrane. The CHIC proteins thus resemble the cysteine string proteins, which function in regulated exocytosis. JF - FEBS Lett EP - 209 TI - A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. VL - 492 SP - 204 KW - article KW - c_elegans KW - caenorhabditis_elegans KW - celegans KW - elegans KW - nematode KW - wormbase AU - Cools, J AU - Mentens, N AU - Marynen, P PY - 2001/// UR - http://view.ncbi.nlm.nih.gov/pubmed/11257495 ER -