ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins. Export

@article{citeulike:180244, abstract = {We have isolated a cDNA from human foetal brain cDNA library which encodes a putative transmembrane protein bearing an intracellular protein tyrosine phosphatase (PTPase) like domain. The PTPase like domain contains an alanine to aspartate amino acid change relative to other PTPases in the catalytic core domain. This amino acid change is found in only three other known proteins, islet cell autoantigens; human, murine and rat IA-2, murine IA-2b and its rat orthologue phogrin, which have a similar overall structure to ICAAR, and the recently identified X-linked myotubular myopathy (MTM1) gene. ICAAR, IA-2 and IA-2b clearly represent a new family of PTP-like proteins for which catalytic activity has yet to be demonstrated. An abundant ICAAR mRNA is detectable in the brain and pancreas but not in the other normal human tissues surveyed. We have localised ICAAR to human chromosome 7q36.}, address = {Section of Cell Biology and Experimental Pathology, Haddow Laboratories, Sutton, Surrey, United Kingdom.}, author = {Smith, P. D. and Barker, K. T. and Wang, J. and Lu, Y. J. and Shipley, J. and Crompton, M. R.}, citeulike-article-id = {180244}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8954911}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8954911}, day = {13}, issn = {0006-291X}, journal = {Biochem Biophys Res Commun}, keywords = {dead\_ptp, ptp}, month = {December}, number = {2}, pages = {402--411}, posted-at = {2005-05-04 21:31:48}, priority = {2}, title = {ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8954911}, volume = {229}, year = {1996} }

TY - JOUR ID - citeulike:180244 L3 - citeulike-article-id:180244 N2 - We have isolated a cDNA from human foetal brain cDNA library which encodes a putative transmembrane protein bearing an intracellular protein tyrosine phosphatase (PTPase) like domain. The PTPase like domain contains an alanine to aspartate amino acid change relative to other PTPases in the catalytic core domain. This amino acid change is found in only three other known proteins, islet cell autoantigens; human, murine and rat IA-2, murine IA-2b and its rat orthologue phogrin, which have a similar overall structure to ICAAR, and the recently identified X-linked myotubular myopathy (MTM1) gene. ICAAR, IA-2 and IA-2b clearly represent a new family of PTP-like proteins for which catalytic activity has yet to be demonstrated. An abundant ICAAR mRNA is detectable in the brain and pancreas but not in the other normal human tissues surveyed. We have localised ICAAR to human chromosome 7q36. IS - 2 JF - Biochem Biophys Res Commun SN - 0006-291X AD - Section of Cell Biology and Experimental Pathology, Haddow Laboratories, Sutton, Surrey, United Kingdom. EP - 411 TI - ICAAR, a novel member of a new family of transmembrane, tyrosine phosphatase-like proteins. VL - 229 SP - 402 KW - dead_ptp KW - ptp AU - Smith, PD AU - Barker, KT AU - Wang, J AU - Lu, YJ AU - Shipley, J AU - Crompton, MR PY - 1996/12/13/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8954911 ER -