The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Export

@article{citeulike:180929, abstract = {Differentiation of spermatids into spermatozoa is regulated via phosphorylated RNA-binding proteins that modulate the expression of stage-specific mRNAs. We demonstrate that the phosphoserine, -threonine or -tyrosine, interaction protein, Styx, complexes with a testicular RNA-binding protein and is essential for normal spermiogenesis. Ablation of Styx expression in mouse disrupts round and elongating spermatid development, resulting in a >1,000-fold decrease in spermatozoa production. Moreover, Styx(-/-) males are infertile because of structural head abnormalities in residual epididymal sperm. Immunoprecipitation of Styx with Crhsp-24, a phosphorylated RNA-binding protein implicated in translational repression of histone mRNAs, provides a strategy for regulating posttranscriptional gene expression.}, address = {Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.}, author = {Wishart, M. J. and Dixon, J. E.}, citeulike-article-id = {180929}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.251686198}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11842224}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11842224}, day = {19}, doi = {10.1073/pnas.251686198}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {dead\_ptp, sperm, styx}, month = {February}, number = {4}, pages = {2112--2117}, posted-at = {2005-05-05 19:59:10}, priority = {2}, title = {The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production.}, url = {http://dx.doi.org/10.1073/pnas.251686198}, volume = {99}, year = {2002} }

TY - JOUR ID - citeulike:180929 L3 - citeulike-article-id:180929 N2 - Differentiation of spermatids into spermatozoa is regulated via phosphorylated RNA-binding proteins that modulate the expression of stage-specific mRNAs. We demonstrate that the phosphoserine, -threonine or -tyrosine, interaction protein, Styx, complexes with a testicular RNA-binding protein and is essential for normal spermiogenesis. Ablation of Styx expression in mouse disrupts round and elongating spermatid development, resulting in a >1,000-fold decrease in spermatozoa production. Moreover, Styx(-/-) males are infertile because of structural head abnormalities in residual epididymal sperm. Immunoprecipitation of Styx with Crhsp-24, a phosphorylated RNA-binding protein implicated in translational repression of histone mRNAs, provides a strategy for regulating posttranscriptional gene expression. IS - 4 JF - Proc Natl Acad Sci U S A SN - 0027-8424 AD - Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. EP - 2117 TI - The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. VL - 99 SP - 2112 KW - dead_ptp KW - sperm KW - styx AU - Wishart, MJ AU - Dixon, JE PY - 2002/02/19/ UR - http://dx.doi.org/10.1073/pnas.251686198 ER -