Molecular Cloning, Chromosomal Mapping, and Developmental Expression of a Novel Protein Tyrosine Phosphatase-like Gene Export

@article{citeulike:180950, abstract = {Protein tyrosine phosphatases (PTPs) mediate the dephosphorylation of phosphotyrosine. PTPs are known to be involved in many signal transduction pathways leading to cell growth, differentiation, and oncogenic transformation. We have cloned a new family of novel protein tyrosine phosphatase-like genes, the Ptpl (protein tyrosine phosphatase-like; proline instead of catalytic arginine) gene family. This gene family is composed of at least three members, and we describe here the developmental expression pattern and chromosomal location for one of these genes, Ptpla. In situ hybridization studies revealed that Ptpla expression was first detected at embryonic day 8.5 in muscle progenitors and later in differentiated muscle types: in the developing heart, throughout the liver and lungs, and in a number of neural crest derivatives including the dorsal root and trigeminal ganglia. Postnatally Ptpla was expressed in a number of adult tissues including cardiac and skeletal muscle, liver, testis, and kidney. The early expression pattern of this gene and its persistent expression in adult tissues suggest that it may have an important role in the development, differentiation, and maintenance of a number of different tissue types. The human homologue of Ptpla (PTPLA) was cloned and shown to map to 10p13-p14.}, author = {Uwanogho, Dafe A. and Hardcastle, Zoe and Balogh, Piroska and Mirza, Ghazala and Thornburg, Kent L. and Ragoussis, Jiannis and Sharpe, Paul T.}, citeulike-article-id = {180950}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/geno.1999.5950}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WG1-45GMFDN-B/2/ccf335e7ccb5da983c1ddc1f303793d3}, day = {15}, doi = {10.1006/geno.1999.5950}, journal = {Genomics}, keywords = {dead\_ptp, ptpl}, month = {December}, number = {3}, pages = {406--416}, posted-at = {2005-05-05 21:10:28}, priority = {2}, title = {Molecular Cloning, Chromosomal Mapping, and Developmental Expression of a Novel Protein Tyrosine Phosphatase-like Gene}, url = {http://dx.doi.org/10.1006/geno.1999.5950}, volume = {62}, year = {1999} }

TY - JOUR ID - citeulike:180950 L3 - citeulike-article-id:180950 N2 - Protein tyrosine phosphatases (PTPs) mediate the dephosphorylation of phosphotyrosine. PTPs are known to be involved in many signal transduction pathways leading to cell growth, differentiation, and oncogenic transformation. We have cloned a new family of novel protein tyrosine phosphatase-like genes, the Ptpl (protein tyrosine phosphatase-like; proline instead of catalytic arginine) gene family. This gene family is composed of at least three members, and we describe here the developmental expression pattern and chromosomal location for one of these genes, Ptpla. In situ hybridization studies revealed that Ptpla expression was first detected at embryonic day 8.5 in muscle progenitors and later in differentiated muscle types: in the developing heart, throughout the liver and lungs, and in a number of neural crest derivatives including the dorsal root and trigeminal ganglia. Postnatally Ptpla was expressed in a number of adult tissues including cardiac and skeletal muscle, liver, testis, and kidney. The early expression pattern of this gene and its persistent expression in adult tissues suggest that it may have an important role in the development, differentiation, and maintenance of a number of different tissue types. The human homologue of Ptpla (PTPLA) was cloned and shown to map to 10p13-p14. IS - 3 JF - Genomics EP - 416 TI - Molecular Cloning, Chromosomal Mapping, and Developmental Expression of a Novel Protein Tyrosine Phosphatase-like Gene VL - 62 SP - 406 KW - dead_ptp KW - ptpl AU - Uwanogho, Dafe AU - Hardcastle, Zoe AU - Balogh, Piroska AU - Mirza, Ghazala AU - Thornburg, Kent AU - Ragoussis, Jiannis AU - Sharpe, Paul PY - 1999/12/15/ UR - http://dx.doi.org/10.1006/geno.1999.5950 ER -