SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans. Export

@article{citeulike:197600, abstract = {The dauer larva of the nematode Caenorhabditis elegans is a good model system for investigating the regulation of developmental fates by environmental cues. Here we show that SDF-9, a protein tyrosine phosphatase-like molecule, is involved in the regulation of dauer larva formation. The dauer larva of sdf-9 mutants is different from a normal dauer larva but resembles the dauer-like larva of daf-9 and daf-12 dauer-constitutive mutants. Like these mutants, the dauer-constitutive phenotypes of sdf-9 mutants were greatly enhanced by cholesterol deprivation. Epistasis analyses, together with the relationship between sdf-9 mutations and daf-9 expression, suggested that SDF-9 increases the activity of DAF-9 or helps the execution of the DAF-9 function. SDF-9 was expressed in two head cells in which DAF-9 is expressed. By their position and by genetic mosaic experiments, we identified these cells as XXXL/R cells, which are known as embryonic hypodermal cells and whose function at later stages is unknown. Killing of the sdf-9-expressing cells in the wild-type first-stage larva induced formation of the dauer-like larva. Since this study on SDF-9 and former studies on DAF-9 showed that the functions of these proteins are related to those of steroids, XXXL/R cells seem to play a key role in the metabolism or function of a steroid hormone(s) that acts in dauer regulation.}, address = {Structural Biology Center, National Institute of Genetics and School of Genetics, Faculty of Life Sciences, Graduate University for Advanced Studies, Mishima, Shizuoka 411-8540, Japan.}, author = {Ohkura, K. and Suzuki, N. and Ishihara, T. and Katsura, I.}, citeulike-article-id = {197600}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12783794}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12783794}, citeulike-linkout-2 = {http://www.wormbase.org/db/misc/paper?name=WBPaper00006015}, issn = {0950-1991}, journal = {Development}, keywords = {celegans, dead\_ptp, ptpl}, month = {July}, number = {14}, pages = {3237--3248}, posted-at = {2005-05-12 19:25:29}, priority = {2}, title = {SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12783794}, volume = {130}, year = {2003} }

TY - JOUR ID - citeulike:197600 L3 - citeulike-article-id:197600 N2 - The dauer larva of the nematode Caenorhabditis elegans is a good model system for investigating the regulation of developmental fates by environmental cues. Here we show that SDF-9, a protein tyrosine phosphatase-like molecule, is involved in the regulation of dauer larva formation. The dauer larva of sdf-9 mutants is different from a normal dauer larva but resembles the dauer-like larva of daf-9 and daf-12 dauer-constitutive mutants. Like these mutants, the dauer-constitutive phenotypes of sdf-9 mutants were greatly enhanced by cholesterol deprivation. Epistasis analyses, together with the relationship between sdf-9 mutations and daf-9 expression, suggested that SDF-9 increases the activity of DAF-9 or helps the execution of the DAF-9 function. SDF-9 was expressed in two head cells in which DAF-9 is expressed. By their position and by genetic mosaic experiments, we identified these cells as XXXL/R cells, which are known as embryonic hypodermal cells and whose function at later stages is unknown. Killing of the sdf-9-expressing cells in the wild-type first-stage larva induced formation of the dauer-like larva. Since this study on SDF-9 and former studies on DAF-9 showed that the functions of these proteins are related to those of steroids, XXXL/R cells seem to play a key role in the metabolism or function of a steroid hormone(s) that acts in dauer regulation. IS - 14 JF - Development SN - 0950-1991 AD - Structural Biology Center, National Institute of Genetics and School of Genetics, Faculty of Life Sciences, Graduate University for Advanced Studies, Mishima, Shizuoka 411-8540, Japan. EP - 3248 TI - SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans. VL - 130 SP - 3237 KW - celegans KW - dead_ptp KW - ptpl AU - Ohkura, K AU - Suzuki, N AU - Ishihara, T AU - Katsura, I PY - 2003/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/12783794 ER -