Accuracy of Helicobacter pylori diagnostic tests in patients with bleeding peptic ulcer: a systematic review and meta-analysis. Export

@article{citeulike:2242314, abstract = {OBJECTIVE: To perform a systematic review and a meta-analysis of diagnostic accuracy of the different tests aimed to detect Helicobacter pylori infection in patients with upper gastrointestinal bleeding (UGIB). METHODS: Selection of studies: assessing the accuracy of H. pylori diagnostic methods in patients with UGIB. Search strategy: electronic bibliographical searches. Data extraction: independently done by two reviewers. Data synthesis: meta-analyses of the different tests were performed combining the sensitivities, specificities, and likelihood ratios (LRs) of the individual studies. RESULTS: Studies showed a high degree of heterogeneity. Pooled sensitivity, specificity, LR+ and LR- (95\% confidence interval (CI)) for the different methods were: Rapid urease test (16 studies/1,417 patients): 0.67 (0.64-0.70), 0.93 (0.90-0.96), 9.6 (5.1-18.1), and 0.31 (0.22-0.44). Histology (10 studies/827 patients): 0.70 (0.66-0.74), 0.90 (0.85-0.94), 6.7 (2.5-18.4), and 0.23 (0.12-0.46). Culture (3 studies/314 patients): 0.45 (0.39-0.51), 0.98 (0.92-1.00), 19.6 (4-96), and 0.31 (0.05-1.9). Urea breath test (8 studies/520 patients): 0.93 (0.90-0.95), 0.92 (0.87-0.96), 9.5 (3.9-23.3), and 0.11 (0.07-0.16). Stool antigen test (6 studies/377 patients): 0.87 (0.82-0.91), 0.70 (0.62-0.78), 2.3 (1.4-4), and 0.2 (0.13-0.3). Serology (9 studies/803 patients): 0.88 (0.85-0.90), 0.69 (0.62-0.75), 2.5 (1.6-4.1), and 0.25 (0.19-0.33). CONCLUSION: Biopsy-based methods, such as rapid urease test, histology, and culture, have a low sensitivity, but a high specificity, in patients with UGIB. The accuracy of 13C-urea breath test remains very high in these patients. Stool antigen test is less accurate in UGIB. Although serology seems not to be influenced by UGIB, it cannot be recommended as the first diagnostic test for H. pylori infection in this setting.}, address = {Department of Gastroenterology, La Princesa University Hospital, Universidad Aut\'{o}noma, Madrid, Spain.}, author = {Gisbert, J. P. and Abraira, V.}, citeulike-article-id = {2242314}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1572-0241.2006.00528.x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16494583}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16494583}, doi = {10.1111/j.1572-0241.2006.00528.x}, issn = {0002-9270}, journal = {Am J Gastroenterol}, keywords = {antigen, diagnosis, helicobacter, pylori, serology}, month = {April}, number = {4}, pages = {848--863}, posted-at = {2009-01-29 23:32:00}, priority = {2}, title = {Accuracy of Helicobacter pylori diagnostic tests in patients with bleeding peptic ulcer: a systematic review and meta-analysis.}, url = {http://dx.doi.org/10.1111/j.1572-0241.2006.00528.x}, volume = {101}, year = {2006} }

TY - JOUR ID - citeulike:2242314 L3 - citeulike-article-id:2242314 N2 - OBJECTIVE: To perform a systematic review and a meta-analysis of diagnostic accuracy of the different tests aimed to detect Helicobacter pylori infection in patients with upper gastrointestinal bleeding (UGIB). METHODS: Selection of studies: assessing the accuracy of H. pylori diagnostic methods in patients with UGIB. Search strategy: electronic bibliographical searches. Data extraction: independently done by two reviewers. Data synthesis: meta-analyses of the different tests were performed combining the sensitivities, specificities, and likelihood ratios (LRs) of the individual studies. RESULTS: Studies showed a high degree of heterogeneity. Pooled sensitivity, specificity, LR+ and LR- (95% confidence interval (CI)) for the different methods were: Rapid urease test (16 studies/1,417 patients): 0.67 (0.64-0.70), 0.93 (0.90-0.96), 9.6 (5.1-18.1), and 0.31 (0.22-0.44). Histology (10 studies/827 patients): 0.70 (0.66-0.74), 0.90 (0.85-0.94), 6.7 (2.5-18.4), and 0.23 (0.12-0.46). Culture (3 studies/314 patients): 0.45 (0.39-0.51), 0.98 (0.92-1.00), 19.6 (4-96), and 0.31 (0.05-1.9). Urea breath test (8 studies/520 patients): 0.93 (0.90-0.95), 0.92 (0.87-0.96), 9.5 (3.9-23.3), and 0.11 (0.07-0.16). Stool antigen test (6 studies/377 patients): 0.87 (0.82-0.91), 0.70 (0.62-0.78), 2.3 (1.4-4), and 0.2 (0.13-0.3). Serology (9 studies/803 patients): 0.88 (0.85-0.90), 0.69 (0.62-0.75), 2.5 (1.6-4.1), and 0.25 (0.19-0.33). CONCLUSION: Biopsy-based methods, such as rapid urease test, histology, and culture, have a low sensitivity, but a high specificity, in patients with UGIB. The accuracy of 13C-urea breath test remains very high in these patients. Stool antigen test is less accurate in UGIB. Although serology seems not to be influenced by UGIB, it cannot be recommended as the first diagnostic test for H. pylori infection in this setting. IS - 4 JF - Am J Gastroenterol SN - 0002-9270 AD - Department of Gastroenterology, La Princesa University Hospital, Universidad Autónoma, Madrid, Spain. EP - 863 TI - Accuracy of Helicobacter pylori diagnostic tests in patients with bleeding peptic ulcer: a systematic review and meta-analysis. VL - 101 SP - 848 KW - antigen KW - diagnosis KW - helicobacter KW - pylori KW - serology AU - Gisbert, JP AU - Abraira, V PY - 2006/04// UR - http://dx.doi.org/10.1111/j.1572-0241.2006.00528.x ER -