Use of corticosteroids in treating infectious diseases. Export

@article{citeulike:2907516, abstract = {Clinicians have generally avoided prescribing corticosteroids for active infection because of their known immunosuppressive effects and concern about long-term complications. We conducted a review of the published randomized, double-blind trials comparing corticosteroids and placebo in infections. Except in some trials of viral infections, sore throat, and cerebral cysticercosis, all patients also received active antimicrobial agents in addition to placebo or corticosteroids. For patients with bacterial meningitis, tuberculous meningitis, tuberculous pericarditis, severe typhoid fever, tetanus, or pneumocystis pneumonia with moderate to severe hypoxemia, treatment with corticosteroids improved patient survival (group 1 infections). For patients with bacterial arthritis, corticosteroids were also beneficial and reduced long-term disability (group 2 infections). For about a dozen other infections, corticosteroids significantly relieved symptoms (group 3 infections), and clinicians should consider using them if symptoms are substantial. Corticosteroids were harmful in 2 infections, viral hepatitis and cerebral malaria (group 5 infections). We conclude that corticosteroids are beneficial and safe for a wide variety of infections, although courses longer than 3 weeks should be withheld from patients with concomitant human immunodeficiency virus infection and low CD4 counts.}, address = {Department of Medicine, University of Washington, Seattle-Puget Sound Veterans Affairs Health Care System, Seattle, WA 98108, USA. Steven.McGee@med.va.gov}, author = {McGee, S. and Hirschmann, J.}, citeulike-article-id = {2907516}, citeulike-linkout-0 = {http://dx.doi.org/10.1001/archinte.168.10.1034}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18504331}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18504331}, day = {26}, doi = {10.1001/archinte.168.10.1034}, issn = {1538-3679}, journal = {Archives of internal medicine}, keywords = {corticosteroids, disease, infectious, steroids}, month = {May}, number = {10}, pages = {1034--1046}, posted-at = {2009-01-28 21:21:11}, priority = {2}, title = {Use of corticosteroids in treating infectious diseases.}, url = {http://dx.doi.org/10.1001/archinte.168.10.1034}, volume = {168}, year = {2008} }

TY - JOUR ID - citeulike:2907516 L3 - citeulike-article-id:2907516 N2 - Clinicians have generally avoided prescribing corticosteroids for active infection because of their known immunosuppressive effects and concern about long-term complications. We conducted a review of the published randomized, double-blind trials comparing corticosteroids and placebo in infections. Except in some trials of viral infections, sore throat, and cerebral cysticercosis, all patients also received active antimicrobial agents in addition to placebo or corticosteroids. For patients with bacterial meningitis, tuberculous meningitis, tuberculous pericarditis, severe typhoid fever, tetanus, or pneumocystis pneumonia with moderate to severe hypoxemia, treatment with corticosteroids improved patient survival (group 1 infections). For patients with bacterial arthritis, corticosteroids were also beneficial and reduced long-term disability (group 2 infections). For about a dozen other infections, corticosteroids significantly relieved symptoms (group 3 infections), and clinicians should consider using them if symptoms are substantial. Corticosteroids were harmful in 2 infections, viral hepatitis and cerebral malaria (group 5 infections). We conclude that corticosteroids are beneficial and safe for a wide variety of infections, although courses longer than 3 weeks should be withheld from patients with concomitant human immunodeficiency virus infection and low CD4 counts. IS - 10 JF - Archives of internal medicine SN - 1538-3679 AD - Department of Medicine, University of Washington, Seattle-Puget Sound Veterans Affairs Health Care System, Seattle, WA 98108, USA. Steven.McGee@med.va.gov EP - 1046 TI - Use of corticosteroids in treating infectious diseases. VL - 168 SP - 1034 KW - corticosteroids KW - disease KW - infectious KW - steroids AU - McGee, S AU - Hirschmann, J PY - 2008/05/26/ UR - http://dx.doi.org/10.1001/archinte.168.10.1034 ER -