Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis. Export

@article{citeulike:314073, abstract = {OBJECTIVES: To clarify the clinical significance of positional down beat nystagmus (pDBN). METHODS: A discussion of the neuro-otological findings in 50 consecutive patients with pDBN. RESULTS: In 38 patients there was evidence of CNS disease (central group) but in 12 there was not (idiopathic group). In the CNS group, presenting symptoms were gait, speech, and autonomic dysfunction whereas in the idiopathic group patients mostly reported positional vertigo. The main neurological and oculomotor signs in the CNS group were explained by cerebellar dysfunction, including 13 patients with multiple system atrophy. In patients with multiple system atrophy with a prominent extrapyramidal component, the presence of pDBN was helpful in the differential diagnosis of atypical parkinsonism. No patient with pDBN had the Arnold-Chiari malformation, a common cause of constant down beat nystagmus (DBN). In the idiopathic group, the pDBN had characteristics which suggested a peripheral labyrinthine disorder: vertigo, adaptation, and habituation. In six patients an additional torsional component was found (concurrently with the pDBN in three). Features unusual for peripheral disorder were: bilateral positive Dix-Hallpike manoeuvre in nine of 12 patients and selective provocation by the straight head-hanging manoeuvre in two. CONCLUSION: It is argued that some patients with idiopathic pDBN have benign paroxysmal positional vertigo (BPPV) with lithiasis of the anterior canal. The torsional component may be weak, because of the predominantly sagittal orientation of the anterior canal, and may not be readily seen clinically. Nystagmus provocation by bilateral Dix-Hallpike and straight head-hanging may be explained by the vertical upwards orientation of the ampullary segment of the anterior canal in the normal upright head position. Such orientation makes right-left specificity with the Dix-Hallpike manoeuvre less important than for posterior canal BPPV. This orientation requires a further downwards movement of the head, often achieved with the straight head-hanging position, to provoke migration of the canaliths. The straight head-hanging manoeuvre should be carried out in all patients with a history of positional vertigo and a negative Dix-Hallpike manoeuvre.}, address = {CHU de Saint Etienne, Hopital Bellevue, Saint Etienne, France.}, author = {Bertholon, P. and Bronstein, A. M. and Davies, R. A. and Rudge, P. and Thilo, K. V.}, citeulike-article-id = {314073}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11861698}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11861698}, issn = {0022-3050}, journal = {J Neurol Neurosurg Psychiatry}, keywords = {bppv}, month = {March}, number = {3}, pages = {366--372}, posted-at = {2008-08-30 07:10:56}, priority = {2}, title = {Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11861698}, volume = {72}, year = {2002} }

TY - JOUR ID - citeulike:314073 L3 - citeulike-article-id:314073 N2 - OBJECTIVES: To clarify the clinical significance of positional down beat nystagmus (pDBN). METHODS: A discussion of the neuro-otological findings in 50 consecutive patients with pDBN. RESULTS: In 38 patients there was evidence of CNS disease (central group) but in 12 there was not (idiopathic group). In the CNS group, presenting symptoms were gait, speech, and autonomic dysfunction whereas in the idiopathic group patients mostly reported positional vertigo. The main neurological and oculomotor signs in the CNS group were explained by cerebellar dysfunction, including 13 patients with multiple system atrophy. In patients with multiple system atrophy with a prominent extrapyramidal component, the presence of pDBN was helpful in the differential diagnosis of atypical parkinsonism. No patient with pDBN had the Arnold-Chiari malformation, a common cause of constant down beat nystagmus (DBN). In the idiopathic group, the pDBN had characteristics which suggested a peripheral labyrinthine disorder: vertigo, adaptation, and habituation. In six patients an additional torsional component was found (concurrently with the pDBN in three). Features unusual for peripheral disorder were: bilateral positive Dix-Hallpike manoeuvre in nine of 12 patients and selective provocation by the straight head-hanging manoeuvre in two. CONCLUSION: It is argued that some patients with idiopathic pDBN have benign paroxysmal positional vertigo (BPPV) with lithiasis of the anterior canal. The torsional component may be weak, because of the predominantly sagittal orientation of the anterior canal, and may not be readily seen clinically. Nystagmus provocation by bilateral Dix-Hallpike and straight head-hanging may be explained by the vertical upwards orientation of the ampullary segment of the anterior canal in the normal upright head position. Such orientation makes right-left specificity with the Dix-Hallpike manoeuvre less important than for posterior canal BPPV. This orientation requires a further downwards movement of the head, often achieved with the straight head-hanging position, to provoke migration of the canaliths. The straight head-hanging manoeuvre should be carried out in all patients with a history of positional vertigo and a negative Dix-Hallpike manoeuvre. IS - 3 JF - J Neurol Neurosurg Psychiatry SN - 0022-3050 AD - CHU de Saint Etienne, Hopital Bellevue, Saint Etienne, France. EP - 372 TI - Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis. VL - 72 SP - 366 KW - bppv AU - Bertholon, P AU - Bronstein, AM AU - Davies, RA AU - Rudge, P AU - Thilo, KV PY - 2002/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/11861698 ER -