Evidence of multiexponential $T_2$ in rat glioblastoma TeX Export

@article{Dortch2009Evidence, abstract = {The aim of this study was to characterize multiexponential T2 (MET2) relaxation in a rat C6 glioblastoma tumor model. To do this, rats (n = 11) were inoculated with the C6 cells via stereotaxic injection into the brain. Ten days later, MET2 measurements were performed in vivo using a single-slice, multi-echo spin-echo sequence at 7.0 T. Tumor signal was biexponential in eight animals with a short-lived T2 component (T2 = 20.7 ± 5.4 ms across samples) representing 6.8 ± 6.2\% of the total signal and a long-lived T2 component (T2 = 76.4 ± 9.3 ms) representing the remaining signal fraction. In contrast, signal from contralateral grey matter was consistently monoexponential (T2 = 48.8 ± 2.3 ms). Additional ex vivo studies (n = 3) and Monte Carlo simulations showed that the in vivo results were not significantly corrupted by partial volume averaging or noise. The underlying physiological origin of the observed MET2 components is unknown; however, MET2 analysis may hold promise as a non-invasive tool for characterizing tumor microenvironment in vivo on a sub-voxel scale. Copyright {\copyright} 2009 John Wiley \& Sons, Ltd.}, address = {Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA; Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA; Physics and Astronomy, Vanderbilt University, Nashville, TN, USA; Cancer Biology, Vanderbilt University, Nashville, TN, USA; Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA}, author = {Dortch, Richard D. and Yankeelov, Thomas E. and Yue, Zoe and Quarles, Christopher C. and Gore, John C. and Does, Mark D.}, citeulike-article-id = {5049415}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/nbm.1374}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122241033/ABSTRACT}, doi = {10.1002/nbm.1374}, journal = {NMR Biomed}, keywords = {brain, cancer, mouse, qt2}, number = {6}, pages = {609--618}, posted-at = {2009-07-03 20:55:00}, priority = {0}, title = {Evidence of multiexponential \${T}\_2\$ in rat glioblastoma}, url = {http://dx.doi.org/10.1002/nbm.1374}, volume = {22}, year = {2009} }

TY - JOUR ID - Dortch2009Evidence L3 - citeulike-article-id:5049415 N2 - The aim of this study was to characterize multiexponential T2 (MET2) relaxation in a rat C6 glioblastoma tumor model. To do this, rats (n = 11) were inoculated with the C6 cells via stereotaxic injection into the brain. Ten days later, MET2 measurements were performed in vivo using a single-slice, multi-echo spin-echo sequence at 7.0 T. Tumor signal was biexponential in eight animals with a short-lived T2 component (T2 = 20.7 ± 5.4 ms across samples) representing 6.8 ± 6.2% of the total signal and a long-lived T2 component (T2 = 76.4 ± 9.3 ms) representing the remaining signal fraction. In contrast, signal from contralateral grey matter was consistently monoexponential (T2 = 48.8 ± 2.3 ms). Additional ex vivo studies (n = 3) and Monte Carlo simulations showed that the in vivo results were not significantly corrupted by partial volume averaging or noise. The underlying physiological origin of the observed MET2 components is unknown; however, MET2 analysis may hold promise as a non-invasive tool for characterizing tumor microenvironment in vivo on a sub-voxel scale. Copyright © 2009 John Wiley & Sons, Ltd. IS - 6 JF - NMR Biomed AD - Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA; Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA; Physics and Astronomy, Vanderbilt University, Nashville, TN, USA; Cancer Biology, Vanderbilt University, Nashville, TN, USA; Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA EP - 618 TI - Evidence of multiexponential ${T}_2$ in rat glioblastoma VL - 22 SP - 609 KW - brain KW - cancer KW - mouse KW - qt2 AU - Dortch, Richard AU - Yankeelov, Thomas AU - Yue, Zoe AU - Quarles, Christopher AU - Gore, John AU - Does, Mark PY - 2009/// UR - http://dx.doi.org/10.1002/nbm.1374 ER -