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Bioreversible phosphate protective groups: Synthesis and stability of model acyloxymethyl phosphates

by: Devendra N. Srivastva, David Farquhar
Bioorganic Chemistry, Vol. 12, No. 2. (March 1984), pp. 118-129, doi:10.1016/0045-2068(84)90022-1  Key: citeulike:11239889

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Abstract

Six bis(acyloxymethyl) esters of phenyl phosphate and benzyl phosphate and three acyloxymethylbenzylphenyl phosphates were prepared. Debenzylation of benzyl analogs gave respective free acids which were isolated as cyclohexylammonium salts. Stability of bis(acyloxymethyl)phenyl phosphates were studied in various aqueous buffers, hog liver esterase, and mice plasma.


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