Transient and Persistent Dendritic Spines in the Neocortex In Vivo Export

@article{citeulike:784084, abstract = {Dendritic spines were imaged over days to months in the apical tufts of neocortical pyramidal neurons (layers 5 and 2/3) in vivo. A fraction of thin spines appeared and disappeared over a few days, while most thick spines persisted for months. In the somatosensory cortex, from postnatal day (PND) 16 to PND 25 spine retractions exceeded additions, resulting in a net loss of spines. The fraction of persistent spines (lifetime ≥ 8 days) grew gradually during development and into adulthood (PND 16–25, 35\%; PND 35–80, 54\%; PND 80–120, 66\%; PND 175–225, 73\%), providing evidence that synaptic circuits continue to stabilize even in the adult brain, long after the closure of known critical periods. In 6-month-old mice, spines turn over more slowly in visual compared to somatosensory cortex, possibly reflecting differences in the capacity for experience-dependent plasticity in these brain regions.}, address = {Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.}, author = {Holtmaat, Anthony J. G. D. and Trachtenberg, Joshua T. and Wilbrecht, Linda and Shepherd, Gordon M. and Zhang, Xiaoqun and Knott, Graham W. and Svoboda, Karel}, citeulike-article-id = {784084}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2005.01.003}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0896627305000048}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15664179}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15664179}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6WSS-4F90JMN-G/2/5dff09afc1b615c48acc13fcd1d6271d}, day = {20}, doi = {10.1016/j.neuron.2005.01.003}, issn = {08966273}, journal = {Neuron}, keywords = {in-vivo, neuroscience, somatosensory, spine, two-photon, visual}, month = {January}, number = {2}, pages = {279--291}, posted-at = {2006-08-03 08:15:45}, priority = {4}, title = {Transient and Persistent Dendritic Spines in the Neocortex In Vivo}, url = {http://dx.doi.org/10.1016/j.neuron.2005.01.003}, volume = {45}, year = {2005} }

TY - JOUR ID - citeulike:784084 L3 - citeulike-article-id:784084 N2 - Dendritic spines were imaged over days to months in the apical tufts of neocortical pyramidal neurons (layers 5 and 2/3) in vivo. A fraction of thin spines appeared and disappeared over a few days, while most thick spines persisted for months. In the somatosensory cortex, from postnatal day (PND) 16 to PND 25 spine retractions exceeded additions, resulting in a net loss of spines. The fraction of persistent spines (lifetime ≥ 8 days) grew gradually during development and into adulthood (PND 16–25, 35%; PND 35–80, 54%; PND 80–120, 66%; PND 175–225, 73%), providing evidence that synaptic circuits continue to stabilize even in the adult brain, long after the closure of known critical periods. In 6-month-old mice, spines turn over more slowly in visual compared to somatosensory cortex, possibly reflecting differences in the capacity for experience-dependent plasticity in these brain regions. IS - 2 JF - Neuron SN - 08966273 AD - Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. EP - 291 TI - Transient and Persistent Dendritic Spines in the Neocortex In Vivo VL - 45 SP - 279 KW - in-vivo KW - neuroscience KW - somatosensory KW - spine KW - two-photon KW - visual AU - Holtmaat, Anthony AU - Trachtenberg, Joshua AU - Wilbrecht, Linda AU - Shepherd, Gordon AU - Zhang, Xiaoqun AU - Knott, Graham AU - Svoboda, Karel PY - 2005/01/20/ UR - http://dx.doi.org/10.1016/j.neuron.2005.01.003 ER -