Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Export

@article{citeulike:1019521, abstract = {Cerebellar long-term depression (LTD) is a model of synaptic memory that requires protein kinase C (PKC) activation and is expressed as a reduction in the number of postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. LTD was absent in cultured cerebellar Purkinje cells from mutant mice lacking the AMPA receptor GluR2 subunit and could be rescued by transient transfection with the wild-type GluR2 subunit. Transfection with a point mutant that eliminated PKC phosphorylation of Ser880 in the carboxy-terminal PDZ ligand of GluR2 failed to restore LTD. In contrast, transfection with a point mutant that mimicked phosphorylation at Ser880 occluded subsequent LTD. Thus, PKC phosphorylation of GluR2 Ser880 is a critical event in the induction of cerebellar LTD.}, address = {Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA.}, author = {Chung, H. J. and Steinberg, J. P. and Huganir, R. L. and Linden, D. J.}, citeulike-article-id = {1019521}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1082915}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12805550}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12805550}, day = {13}, doi = {10.1126/science.1082915}, issn = {1095-9203}, journal = {Science}, keywords = {kt, pkc}, month = {June}, number = {5626}, pages = {1751--1755}, posted-at = {2006-12-30 03:24:27}, priority = {2}, title = {Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression.}, url = {http://dx.doi.org/10.1126/science.1082915}, volume = {300}, year = {2003} }

TY - JOUR ID - citeulike:1019521 L3 - citeulike-article-id:1019521 N2 - Cerebellar long-term depression (LTD) is a model of synaptic memory that requires protein kinase C (PKC) activation and is expressed as a reduction in the number of postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. LTD was absent in cultured cerebellar Purkinje cells from mutant mice lacking the AMPA receptor GluR2 subunit and could be rescued by transient transfection with the wild-type GluR2 subunit. Transfection with a point mutant that eliminated PKC phosphorylation of Ser880 in the carboxy-terminal PDZ ligand of GluR2 failed to restore LTD. In contrast, transfection with a point mutant that mimicked phosphorylation at Ser880 occluded subsequent LTD. Thus, PKC phosphorylation of GluR2 Ser880 is a critical event in the induction of cerebellar LTD. IS - 5626 JF - Science SN - 1095-9203 AD - Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA. EP - 1755 TI - Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. VL - 300 SP - 1751 KW - kt KW - pkc AU - Chung, HJ AU - Steinberg, JP AU - Huganir, RL AU - Linden, DJ PY - 2003/06/13/ UR - http://dx.doi.org/10.1126/science.1082915 ER -