Ca(2+)-Stimulated Adenylyl Cyclases Regulate ERK-Dependent Activation of MSK1 during Fear Conditioning. Export

@article{citeulike:1048639, abstract = {The cAMP and ERK/MAP kinase (MAPK) signal transduction pathways are critical for hippocampus-dependent memory, a process that depends on CREB-mediated transcription. However, the extent of crosstalk between these pathways and the downstream CREB kinase activated during memory formation has not been elucidated. Here we report that PKA, MAPK, and MSK1, a CREB kinase, are coactivated in a subset of hippocampal CA1 pyramidal neurons following contextual fear conditioning. Activation of PKA, MAPK, MSK1, and CREB is absolutely dependent on Ca(2+)-stimulated adenylyl cyclase activity. We conclude that adenylyl cyclase activity supports the activation of MAPK, and that MSK1 is the major CREB kinase activated during training for contextual memory.}, address = {Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.}, author = {Sindreu, C. B. and Scheiner, Z. S. and Storm, D. R.}, citeulike-article-id = {1048639}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2006.11.024}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17196532}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17196532}, day = {4}, doi = {10.1016/j.neuron.2006.11.024}, issn = {0896-6273}, journal = {Neuron}, keywords = {ca1, erk, pka}, month = {January}, number = {1}, pages = {79--89}, posted-at = {2007-01-18 06:04:58}, priority = {0}, title = {Ca(2+)-Stimulated Adenylyl Cyclases Regulate ERK-Dependent Activation of MSK1 during Fear Conditioning.}, url = {http://dx.doi.org/10.1016/j.neuron.2006.11.024}, volume = {53}, year = {2007} }

TY - JOUR ID - citeulike:1048639 L3 - citeulike-article-id:1048639 N2 - The cAMP and ERK/MAP kinase (MAPK) signal transduction pathways are critical for hippocampus-dependent memory, a process that depends on CREB-mediated transcription. However, the extent of crosstalk between these pathways and the downstream CREB kinase activated during memory formation has not been elucidated. Here we report that PKA, MAPK, and MSK1, a CREB kinase, are coactivated in a subset of hippocampal CA1 pyramidal neurons following contextual fear conditioning. Activation of PKA, MAPK, MSK1, and CREB is absolutely dependent on Ca(2+)-stimulated adenylyl cyclase activity. We conclude that adenylyl cyclase activity supports the activation of MAPK, and that MSK1 is the major CREB kinase activated during training for contextual memory. IS - 1 JF - Neuron SN - 0896-6273 AD - Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. EP - 89 TI - Ca(2+)-Stimulated Adenylyl Cyclases Regulate ERK-Dependent Activation of MSK1 during Fear Conditioning. VL - 53 SP - 79 KW - ca1 KW - erk KW - pka AU - Sindreu, CB AU - Scheiner, ZS AU - Storm, DR PY - 2007/01/04/ UR - http://dx.doi.org/10.1016/j.neuron.2006.11.024 ER -