Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit. Export

@article{citeulike:1159134, abstract = {Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.}, address = {Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.}, author = {Lamsa, K. P. and Heeroma, J. H. and Somogyi, P. and Rusakov, D. A. and Kullmann, D. M.}, citeulike-article-id = {1159134}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1137450}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/315/5816/1262}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17332410}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17332410}, day = {2}, doi = {10.1126/science.1137450}, issn = {1095-9203}, journal = {Science}, keywords = {ca1, cpampar, ltp}, month = {March}, number = {5816}, pages = {1262--1266}, posted-at = {2007-03-14 07:41:02}, priority = {0}, title = {Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit.}, url = {http://dx.doi.org/10.1126/science.1137450}, volume = {315}, year = {2007} }

TY - JOUR ID - citeulike:1159134 L3 - citeulike-article-id:1159134 N2 - Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity. IS - 5816 JF - Science SN - 1095-9203 AD - Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. EP - 1266 TI - Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit. VL - 315 SP - 1262 KW - ca1 KW - cpampar KW - ltp AU - Lamsa, KP AU - Heeroma, JH AU - Somogyi, P AU - Rusakov, DA AU - Kullmann, DM PY - 2007/03/02/ UR - http://dx.doi.org/10.1126/science.1137450 ER -