Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. Export

@article{citeulike:1165363, abstract = {Fear conditioning is a paradigm that has been used as a model for emotional learning in animals. The cellular correlate of fear conditioning is thought to be associative N-methyl-D-aspartate (NMDA) receptor-dependent synaptic plasticity within the amygdala. Here we show that glutamatergic synaptic transmission to inhibitory interneurons in the basolateral amygdala is mediated solely by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. In contrast to AMPA receptors at inputs to pyramidal neurons, these receptors have an inwardly rectifying current-voltage relationship, indicative of a high permeability to calcium. Tetanic stimulation of inputs to interneurons caused an immediate and sustained increase in the efficacy of these synapses. This potentiation required a rise in postsynaptic calcium, but was independent of NMDA receptor activation. The potentiation of excitatory inputs to interneurons was reflected as an increase in the amplitude of the GABA(A)-mediated inhibitory synaptic current in pyramidal neurons. These results demonstrate that excitatory synapses onto interneurons within a fear conditioning circuit show NMDA-receptor independent long-term potentiation. This plasticity might underlie the increased synchronization of activity between neurons in the basolateral amygdala after fear conditioning.}, address = {The Neuroscience Group, Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia.}, author = {Mahanty, N. K. and Sah, P.}, citeulike-article-id = {1165363}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/29312}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/9716132}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=9716132}, day = {13}, doi = {10.1038/29312}, issn = {0028-0836}, journal = {Nature}, keywords = {amygdala, cpampar, interneuron, ltp}, month = {August}, number = {6694}, pages = {683--687}, posted-at = {2007-03-15 11:46:23}, priority = {0}, title = {Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala.}, url = {http://dx.doi.org/10.1038/29312}, volume = {394}, year = {1998} }

TY - JOUR ID - citeulike:1165363 L3 - citeulike-article-id:1165363 N2 - Fear conditioning is a paradigm that has been used as a model for emotional learning in animals. The cellular correlate of fear conditioning is thought to be associative N-methyl-D-aspartate (NMDA) receptor-dependent synaptic plasticity within the amygdala. Here we show that glutamatergic synaptic transmission to inhibitory interneurons in the basolateral amygdala is mediated solely by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. In contrast to AMPA receptors at inputs to pyramidal neurons, these receptors have an inwardly rectifying current-voltage relationship, indicative of a high permeability to calcium. Tetanic stimulation of inputs to interneurons caused an immediate and sustained increase in the efficacy of these synapses. This potentiation required a rise in postsynaptic calcium, but was independent of NMDA receptor activation. The potentiation of excitatory inputs to interneurons was reflected as an increase in the amplitude of the GABA(A)-mediated inhibitory synaptic current in pyramidal neurons. These results demonstrate that excitatory synapses onto interneurons within a fear conditioning circuit show NMDA-receptor independent long-term potentiation. This plasticity might underlie the increased synchronization of activity between neurons in the basolateral amygdala after fear conditioning. IS - 6694 JF - Nature SN - 0028-0836 AD - The Neuroscience Group, Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia. EP - 687 TI - Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. VL - 394 SP - 683 KW - amygdala KW - cpampar KW - interneuron KW - ltp AU - Mahanty, NK AU - Sah, P PY - 1998/08/13/ UR - http://dx.doi.org/10.1038/29312 ER -