The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Export

@article{citeulike:1479758, abstract = {Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine (val) to methionine (met) substitution in the 5' pro-region of the human BDNF protein. In human subjects, the met allele was associated with poorer episodic memory, abnormal hippocampal activation assayed with fMRI, and lower hippocampal n-acetyl aspartate (NAA), assayed with MRI spectroscopy. Neurons transfected with met-BDNF-GFP showed lower depolarization-induced secretion, while constitutive secretion was unchanged. Furthermore, met-BDNF-GFP failed to localize to secretory granules or synapses. These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.}, address = {Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s-235, 10 Center Drive, Bethesda, MD 20892, USA.}, author = {Egan, Michael F. and Kojima, Masami and Callicott, Joseph H. and Goldberg, Terry E. and Kolachana, Bhaskar S. and Bertolino, Alessandro and Zaitsev, Eugene and Gold, Bert and Goldman, David and Dean, Michael and Lu, Bai and Weinberger, Daniel R.}, citeulike-article-id = {1479758}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12553913}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12553913}, day = {24}, issn = {0092-8674}, journal = {Cell}, keywords = {human, memory}, month = {January}, number = {2}, pages = {257--269}, posted-at = {2007-07-25 03:36:49}, priority = {2}, title = {The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12553913}, volume = {112}, year = {2003} }

TY - JOUR ID - citeulike:1479758 L3 - citeulike-article-id:1479758 N2 - Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity and hippocampal-dependent memory in cell models and in animals. We examined the effects of a valine (val) to methionine (met) substitution in the 5' pro-region of the human BDNF protein. In human subjects, the met allele was associated with poorer episodic memory, abnormal hippocampal activation assayed with fMRI, and lower hippocampal n-acetyl aspartate (NAA), assayed with MRI spectroscopy. Neurons transfected with met-BDNF-GFP showed lower depolarization-induced secretion, while constitutive secretion was unchanged. Furthermore, met-BDNF-GFP failed to localize to secretory granules or synapses. These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF. IS - 2 JF - Cell SN - 0092-8674 AD - Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s-235, 10 Center Drive, Bethesda, MD 20892, USA. EP - 269 TI - The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. VL - 112 SP - 257 KW - human KW - memory AU - Egan, Michael AU - Kojima, Masami AU - Callicott, Joseph AU - Goldberg, Terry AU - Kolachana, Bhaskar AU - Bertolino, Alessandro AU - Zaitsev, Eugene AU - Gold, Bert AU - Goldman, David AU - Dean, Michael AU - Lu, Bai AU - Weinberger, Daniel PY - 2003/01/24/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12553913 ER -