LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Export

@article{citeulike:1653882, abstract = {In the CA1 region of the rat hippocampus, long-term potentiation (LTP) requires the activation of NMDA receptors (NMDARs) and leads to an enhancement of AMPA receptor (AMPAR) function. In neonatal hippocampus, this increase in synaptic strength seems to be mediated by delivery of AMPARs to the synapse. Here we studied changes in surface expression of native AMPA and NMDA receptors following induction of LTP in the adult rat brain. In contrast to early postnatal rats, we find that LTP in the adult rat does not alter membrane association of AMPARs. Instead, LTP leads to rapid surface expression of NMDARs in a PKC- and Src-family-dependent manner. The present study suggests a developmental shift in the LTP-dependent trafficking of AMPA receptors. Moreover, our results indicate that insertion of NMDA receptors may be a key step in regulating synaptic plasticity.}, address = {Department of Pharmacology, University of Colorado Health Science Center, 4200 E. Ninth Ave. Box C236, Denver, Colorado 80262, USA.}, author = {Grosshans, D. R. and Clayton, D. A. and Coultrap, S. J. and Browning, M. D.}, citeulike-article-id = {1653882}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn779}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11740502}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11740502}, doi = {10.1038/nn779}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {ca1, nmdar}, month = {January}, number = {1}, pages = {27--33}, posted-at = {2007-09-14 02:59:24}, priority = {2}, title = {LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1.}, url = {http://dx.doi.org/10.1038/nn779}, volume = {5}, year = {2002} }

TY - JOUR ID - citeulike:1653882 L3 - citeulike-article-id:1653882 N2 - In the CA1 region of the rat hippocampus, long-term potentiation (LTP) requires the activation of NMDA receptors (NMDARs) and leads to an enhancement of AMPA receptor (AMPAR) function. In neonatal hippocampus, this increase in synaptic strength seems to be mediated by delivery of AMPARs to the synapse. Here we studied changes in surface expression of native AMPA and NMDA receptors following induction of LTP in the adult rat brain. In contrast to early postnatal rats, we find that LTP in the adult rat does not alter membrane association of AMPARs. Instead, LTP leads to rapid surface expression of NMDARs in a PKC- and Src-family-dependent manner. The present study suggests a developmental shift in the LTP-dependent trafficking of AMPA receptors. Moreover, our results indicate that insertion of NMDA receptors may be a key step in regulating synaptic plasticity. IS - 1 JF - Nat Neurosci SN - 1097-6256 AD - Department of Pharmacology, University of Colorado Health Science Center, 4200 E. Ninth Ave. Box C236, Denver, Colorado 80262, USA. EP - 33 TI - LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. VL - 5 SP - 27 KW - ca1 KW - nmdar AU - Grosshans, DR AU - Clayton, DA AU - Coultrap, SJ AU - Browning, MD PY - 2002/01// UR - http://dx.doi.org/10.1038/nn779 ER -