ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors. Export

@article{citeulike:694555, abstract = {MAP kinase (ERK) translates cell surface signals into alterations in transcription. We have found that ERK also regulates hippocampal neuronal excitability during 5 Hz stimulation and thereby regulates forms of long-term potentiation (LTP) that do not require macromolecular synthesis. Moreover, ERK-mediated changes in excitability are selectively required for some forms of LTP but not others. ERK is required for the early phase of LTP elicited by brief 5 Hz stimulation, as well as for LTP elicited by more prolonged 5 Hz stimulation when paired with beta1-adrenergic receptor activation. By contrast, ERK plays no role in LTP elicited by a single 1 s 100 Hz train. Consistent with these results, we find that ERK is activated by beta-adrenergic receptors in CA1 pyramidal cell somas and dendrites.}, address = {Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York 10032, USA.}, author = {Winder, D. G. and Martin, K. C. and Muzzio, I. A. and Rohrer, D. and Chruscinski, A. and Kobilka, B. and Kandel, E. R.}, citeulike-article-id = {694555}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10595521}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10595521}, issn = {0896-6273}, journal = {Neuron}, keywords = {bar, ca1, erk, excitability}, month = {November}, number = {3}, pages = {715--726}, posted-at = {2006-06-13 11:28:23}, priority = {0}, title = {ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10595521}, volume = {24}, year = {1999} }

TY - JOUR ID - citeulike:694555 L3 - citeulike-article-id:694555 N2 - MAP kinase (ERK) translates cell surface signals into alterations in transcription. We have found that ERK also regulates hippocampal neuronal excitability during 5 Hz stimulation and thereby regulates forms of long-term potentiation (LTP) that do not require macromolecular synthesis. Moreover, ERK-mediated changes in excitability are selectively required for some forms of LTP but not others. ERK is required for the early phase of LTP elicited by brief 5 Hz stimulation, as well as for LTP elicited by more prolonged 5 Hz stimulation when paired with beta1-adrenergic receptor activation. By contrast, ERK plays no role in LTP elicited by a single 1 s 100 Hz train. Consistent with these results, we find that ERK is activated by beta-adrenergic receptors in CA1 pyramidal cell somas and dendrites. IS - 3 JF - Neuron SN - 0896-6273 AD - Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York 10032, USA. EP - 726 TI - ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors. VL - 24 SP - 715 KW - bar KW - ca1 KW - erk KW - excitability AU - Winder, DG AU - Martin, KC AU - Muzzio, IA AU - Rohrer, D AU - Chruscinski, A AU - Kobilka, B AU - Kandel, ER PY - 1999/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/10595521 ER -