Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD. Export

@article{citeulike:715586, abstract = {Activation of adrenoreceptors modulates synaptic transmission in the basolateral amygdala. Here, we investigated the effects of alpha2-adrenoreceptor activation on long-term depression and long-term potentiation in an in vitro slice preparation of the mouse basolateral amygdala. Field potentials and excitatory postsynaptic currents were evoked in the basolateral amygdala by stimulating the lateral amygdala. Norepinephrine (20 micro m) reduced synaptic transmission and completely blocked the induction of long-term potentiation and long-term depression. The alpha2-adrenoreceptor antagonist yohimbine (2 micro m) reversed this effect. The alpha2-adrenoreceptor agonist clonidine (10 micro m) mimicked the effects of norepinephrine. The Gi/o-protein inhibitor pertussis toxin (5 micro g/mL) reversed the effect of clonidine. Long-term depression was blocked in the presence of omega-conotoxin GVIA, but not omega-agatoxin IVA. Clonidine inhibited voltage-activated Ca2+ currents mediated via N- or P/Q-type Ca2+-channels. The inhibitory action of clonidine on long-term depression was reversed when inwardly rectifying K+-channels were blocked by Ba2+ (300 micro m). The present data suggest that alpha2-adrenoreceptor activation impairs the induction of long-term depression in the basolateral amygdala by a Gi/o-protein-mediated inhibition of presynaptic N-type Ca2+-channels and activation of inwardly-rectifying K+-channels.}, address = {Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, D-80804 M\"{u}nchen, Germany.}, author = {DeBock, F. and Kurz, J. and Azad, S. C. and Parsons, C. G. and Hapfelmeier, G. and Zieglg\"{a}nsberger, W. and Rammes, G.}, citeulike-article-id = {715586}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12713644}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12713644}, issn = {0953-816X}, journal = {Eur J Neurosci}, keywords = {aar, bla, ltp}, month = {April}, number = {7}, pages = {1411--1424}, posted-at = {2006-06-29 12:38:33}, priority = {0}, title = {Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12713644}, volume = {17}, year = {2003} }

TY - JOUR ID - citeulike:715586 L3 - citeulike-article-id:715586 N2 - Activation of adrenoreceptors modulates synaptic transmission in the basolateral amygdala. Here, we investigated the effects of alpha2-adrenoreceptor activation on long-term depression and long-term potentiation in an in vitro slice preparation of the mouse basolateral amygdala. Field potentials and excitatory postsynaptic currents were evoked in the basolateral amygdala by stimulating the lateral amygdala. Norepinephrine (20 micro m) reduced synaptic transmission and completely blocked the induction of long-term potentiation and long-term depression. The alpha2-adrenoreceptor antagonist yohimbine (2 micro m) reversed this effect. The alpha2-adrenoreceptor agonist clonidine (10 micro m) mimicked the effects of norepinephrine. The Gi/o-protein inhibitor pertussis toxin (5 micro g/mL) reversed the effect of clonidine. Long-term depression was blocked in the presence of omega-conotoxin GVIA, but not omega-agatoxin IVA. Clonidine inhibited voltage-activated Ca2+ currents mediated via N- or P/Q-type Ca2+-channels. The inhibitory action of clonidine on long-term depression was reversed when inwardly rectifying K+-channels were blocked by Ba2+ (300 micro m). The present data suggest that alpha2-adrenoreceptor activation impairs the induction of long-term depression in the basolateral amygdala by a Gi/o-protein-mediated inhibition of presynaptic N-type Ca2+-channels and activation of inwardly-rectifying K+-channels. IS - 7 JF - Eur J Neurosci SN - 0953-816X AD - Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, D-80804 München, Germany. EP - 1424 TI - Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD. VL - 17 SP - 1411 KW - aar KW - bla KW - ltp AU - DeBock, F AU - Kurz, J AU - Azad, SC AU - Parsons, CG AU - Hapfelmeier, G AU - Zieglgänsberger, W AU - Rammes, G PY - 2003/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/12713644 ER -