LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites. Export

@article{citeulike:887227, abstract = {The propagation and integration of signals in the dendrites of pyramidal neurons is regulated, in part, by the distribution and biophysical properties of voltage-gated ion channels. It is thus possible that any modification of these channels in a specific part of the dendritic tree might locally alter these signaling processes. Using dendritic and somatic whole-cell recordings, combined with calcium imaging in rat hippocampal slices, we found that the induction of long-term potentiation (LTP) was accompanied by a local increase in dendritic excitability that was dependent on the activation of NMDA receptors. These changes favored the back-propagation of action potentials into this dendritic region with a subsequent boost in the Ca(2+) influx. Dendritic cell-attached patch recordings revealed a hyperpolarized shift in the inactivation curve of transient, A-type K(+) currents that can account for the enhanced excitability. These results suggest an important mechanism associated with LTP for shaping signal processing and controlling dendritic function.}, address = {Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.}, author = {Frick, A. and Magee, J. and Johnston, D.}, citeulike-article-id = {887227}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn1178}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn1178}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/14730307}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=14730307}, doi = {10.1038/nn1178}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {acurrent, ca1, excitability, ltp}, month = {February}, number = {2}, pages = {126--135}, posted-at = {2006-12-30 08:43:03}, priority = {5}, title = {LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites.}, url = {http://dx.doi.org/10.1038/nn1178}, volume = {7}, year = {2004} }

TY - JOUR ID - citeulike:887227 L3 - citeulike-article-id:887227 N2 - The propagation and integration of signals in the dendrites of pyramidal neurons is regulated, in part, by the distribution and biophysical properties of voltage-gated ion channels. It is thus possible that any modification of these channels in a specific part of the dendritic tree might locally alter these signaling processes. Using dendritic and somatic whole-cell recordings, combined with calcium imaging in rat hippocampal slices, we found that the induction of long-term potentiation (LTP) was accompanied by a local increase in dendritic excitability that was dependent on the activation of NMDA receptors. These changes favored the back-propagation of action potentials into this dendritic region with a subsequent boost in the Ca(2+) influx. Dendritic cell-attached patch recordings revealed a hyperpolarized shift in the inactivation curve of transient, A-type K(+) currents that can account for the enhanced excitability. These results suggest an important mechanism associated with LTP for shaping signal processing and controlling dendritic function. IS - 2 JF - Nat Neurosci SN - 1097-6256 AD - Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. EP - 135 TI - LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites. VL - 7 SP - 126 KW - acurrent KW - ca1 KW - excitability KW - ltp AU - Frick, A AU - Magee, J AU - Johnston, D PY - 2004/02// UR - http://dx.doi.org/10.1038/nn1178 ER -