Evolutionarily Conserved Herpesviral Protein Interaction Networks Export

@article{fossum-haas-conserved-herpesviral-pins-plos-pathogens-2009, abstract = {Author Summary Herpesvirus proteins interact with each other in a complex manner throughout the infectious cycle. This is probably best exemplified in the process where a large number of viral proteins come together to form new viral particles which are subsequently released from the infected cell. A more detailed understanding of how viral proteins interact with each other might assist the development of drugs which may inhibit these interactions and consequently block viral replication. Here we present three genome-wide studies of protein-protein interactions in the herpesviruses herpes simplex virus I, murine cytomegalovirus and Epstein-Barr virus. Altogether we identified 735 interactions in the three viruses, most of which have not previously been reported. By combining these studies with our previously published studies for Kaposi's sarcoma-associated herpesvirus and varicella-zoster virus we were able to perform a comparative analysis of interactions in five related viral species. We observed that a high proportion of interactions were conserved between the different species, despite a low degree of sequence conservation. This implies that by comparing interaction data, we were able to increase the coverage of our viral networks and thus obtain a better and more complete picture of interactions between herpesviral proteins.}, author = {Fossum, Even and Friedel, Caroline C. and Rajagopala, Seesandra V. and Titz, Bj\"{o}rn and Baiker, Armin and Schmidt, Tina and Kraus, Theo and Stellberger, Thorsten and Rutenberg, Christiane and Suthram, Silpa and Bandyopadhyay, Sourav and Rose, Dietlind and von Brunn, Albrecht and Uhlmann, Mareike and Zeretzke, Christine and Dong, Yu-An and Boulet, H\'{e}l\`{e}ne and Koegl, Manfred and Bailer, Susanne M. and Koszinowski, Ulrich and Ideker, Trey and Uetz, Peter and Zimmer, Ralf and Haas, J\"{u}rgen}, citeulike-article-id = {5804921}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.ppat.1000570}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19730696}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19730696}, day = {4}, doi = {10.1371/journal.ppat.1000570}, issn = {1553-7374}, journal = {PLoS Pathog}, keywords = {host-pathogen, host-pathogen-dataset}, month = {September}, number = {9}, pages = {e1000570+}, posted-at = {2009-09-29 01:50:28}, priority = {2}, publisher = {Public Library of Science}, title = {Evolutionarily Conserved Herpesviral Protein Interaction Networks}, url = {http://dx.doi.org/10.1371/journal.ppat.1000570}, volume = {5}, year = {2009} }

TY - JOUR ID - fossum-haas-conserved-herpesviral-pins-plos-pathogens-2009 L3 - citeulike-article-id:5804921 N2 - Author Summary Herpesvirus proteins interact with each other in a complex manner throughout the infectious cycle. This is probably best exemplified in the process where a large number of viral proteins come together to form new viral particles which are subsequently released from the infected cell. A more detailed understanding of how viral proteins interact with each other might assist the development of drugs which may inhibit these interactions and consequently block viral replication. Here we present three genome-wide studies of protein-protein interactions in the herpesviruses herpes simplex virus I, murine cytomegalovirus and Epstein-Barr virus. Altogether we identified 735 interactions in the three viruses, most of which have not previously been reported. By combining these studies with our previously published studies for Kaposi's sarcoma-associated herpesvirus and varicella-zoster virus we were able to perform a comparative analysis of interactions in five related viral species. We observed that a high proportion of interactions were conserved between the different species, despite a low degree of sequence conservation. This implies that by comparing interaction data, we were able to increase the coverage of our viral networks and thus obtain a better and more complete picture of interactions between herpesviral proteins. IS - 9 JF - PLoS Pathog SN - 1553-7374 TI - Evolutionarily Conserved Herpesviral Protein Interaction Networks PB - Public Library of Science VL - 5 SP - e1000570 KW - host-pathogen KW - host-pathogen-dataset AU - Fossum, Even AU - Friedel, Caroline AU - Rajagopala, Seesandra AU - Titz, Björn AU - Baiker, Armin AU - Schmidt, Tina AU - Kraus, Theo AU - Stellberger, Thorsten AU - Rutenberg, Christiane AU - Suthram, Silpa AU - Bandyopadhyay, Sourav AU - Rose, Dietlind AU - von Brunn, Albrecht AU - Uhlmann, Mareike AU - Zeretzke, Christine AU - Dong, Yu-An AU - Boulet, Hélène AU - Koegl, Manfred AU - Bailer, Susanne AU - Koszinowski, Ulrich AU - Ideker, Trey AU - Uetz, Peter AU - Zimmer, Ralf AU - Haas, Jürgen PY - 2009/09/04/ UR - http://dx.doi.org/10.1371/journal.ppat.1000570 ER -