Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism Export

@article{Destexhe1994_markov_theory, abstract = {Markov kinetic models were used to synthesize a complete description of synaptic transmission, including opening of voltage-dependent channels in the presynaptic terminal, release of neurotransmitter, gating of postsynaptic receptors, and activation of second-messenger systems. These kinetic schemes provide a more general framework for modeling ion channels than the Hodgkin-Huxley formalism, supporting a continuous spectrum of descriptions ranging from the very simple and computationally efficient to the highly complex and biophysically precise. Examples are given of simple kinetic schemes based on fits to experimental data that capture the essential properties of voltage-gated, synaptic and neuromodulatory currents. The Markov formalism allows the dynamics of ionic currents to be considered naturally in the larger context of biochemical signal transduction. This framework can facilitate the integration of a wide range of experimental data and promote consistent theoretical analysis of neural mechanisms from molecular interactions to network computations.}, author = {Destexhe, Alain and Mainen, Zachary F. and Sejnowski, Terrence J.}, citeulike-article-id = {1097873}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/BF00961734}, citeulike-linkout-1 = {http://www.springerlink.com/content/h394424x0146k28m}, day = {1}, doi = {10.1007/BF00961734}, journal = {Journal of Computational Neuroscience}, keywords = {hh, markov, modelling}, month = {August}, number = {3}, pages = {195--230}, posted-at = {2007-02-10 07:47:16}, priority = {0}, title = {Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism}, url = {http://dx.doi.org/10.1007/BF00961734}, volume = {1}, year = {1994} }

TY - JOUR ID - Destexhe1994_markov_theory L3 - citeulike-article-id:1097873 N2 - Markov kinetic models were used to synthesize a complete description of synaptic transmission, including opening of voltage-dependent channels in the presynaptic terminal, release of neurotransmitter, gating of postsynaptic receptors, and activation of second-messenger systems. These kinetic schemes provide a more general framework for modeling ion channels than the Hodgkin-Huxley formalism, supporting a continuous spectrum of descriptions ranging from the very simple and computationally efficient to the highly complex and biophysically precise. Examples are given of simple kinetic schemes based on fits to experimental data that capture the essential properties of voltage-gated, synaptic and neuromodulatory currents. The Markov formalism allows the dynamics of ionic currents to be considered naturally in the larger context of biochemical signal transduction. This framework can facilitate the integration of a wide range of experimental data and promote consistent theoretical analysis of neural mechanisms from molecular interactions to network computations. IS - 3 JF - Journal of Computational Neuroscience EP - 230 TI - Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism VL - 1 SP - 195 KW - hh KW - markov KW - modelling AU - Destexhe, Alain AU - Mainen, Zachary AU - Sejnowski, Terrence PY - 1994/08/01/ UR - http://dx.doi.org/10.1007/BF00961734 ER -