Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology. Export

@article{citeulike:989751, abstract = {The long QT syndrome (LQTS) is a genetic disorder, typically characterized by a prolonged QT interval in the ECG due to abnormal cardiac repolarization. LQTS may lead to syncopal episodes and sudden cardiac death. Various parameters based on T-wave morphology, as well as the QT interval itself have been shown to be useful discriminators, but no single ECG parameter has been sufficient to solve the diagnostic problem. In this study we present a method for discrimination among persons with a normal genotype and those with mutations in the KCNQ1 (KvLQT1 or LQT1) and KCNH2 (HERG or LQT2) genes on the basis of parameters describing T-wave morphology in terms of duration, asymmetry, flatness and amplitude. Discriminant analyses based on 4 or 5 parameters both resulted in perfect discrimination in a learning set of 36 subjects. In both cases cross-validation of the resulting classifiers showed no misclassifications either.}, address = {Department of Health Science and Technology, Center for Sensory Motor Interaction (SMI), Fredrik Bajers Vej 7D3, 9220, Aalborg, Denmark, jjs@hst.aau.dk.}, author = {Struijk, J. J. and Kanters, J. K. and Andersen, M. P. and Hardahl, T. and Graff, C. and Christiansen, M. and Toft, E.}, citeulike-article-id = {989751}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s11517-006-0061-1}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16937190}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16937190}, doi = {10.1007/s11517-006-0061-1}, issn = {0140-0118}, journal = {Med Biol Eng Comput}, keywords = {lqts, morphology, t-wave}, month = {July}, number = {7}, pages = {543--549}, posted-at = {2006-12-12 13:20:49}, priority = {0}, title = {Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology.}, url = {http://dx.doi.org/10.1007/s11517-006-0061-1}, volume = {44}, year = {2006} }

TY - JOUR ID - citeulike:989751 L3 - citeulike-article-id:989751 N2 - The long QT syndrome (LQTS) is a genetic disorder, typically characterized by a prolonged QT interval in the ECG due to abnormal cardiac repolarization. LQTS may lead to syncopal episodes and sudden cardiac death. Various parameters based on T-wave morphology, as well as the QT interval itself have been shown to be useful discriminators, but no single ECG parameter has been sufficient to solve the diagnostic problem. In this study we present a method for discrimination among persons with a normal genotype and those with mutations in the KCNQ1 (KvLQT1 or LQT1) and KCNH2 (HERG or LQT2) genes on the basis of parameters describing T-wave morphology in terms of duration, asymmetry, flatness and amplitude. Discriminant analyses based on 4 or 5 parameters both resulted in perfect discrimination in a learning set of 36 subjects. In both cases cross-validation of the resulting classifiers showed no misclassifications either. IS - 7 JF - Med Biol Eng Comput SN - 0140-0118 AD - Department of Health Science and Technology, Center for Sensory Motor Interaction (SMI), Fredrik Bajers Vej 7D3, 9220, Aalborg, Denmark, jjs@hst.aau.dk. EP - 549 TI - Classification of the long-QT syndrome based on discriminant analysis of T-wave morphology. VL - 44 SP - 543 KW - lqts KW - morphology KW - t-wave AU - Struijk, JJ AU - Kanters, JK AU - Andersen, MP AU - Hardahl, T AU - Graff, C AU - Christiansen, M AU - Toft, E PY - 2006/07// UR - http://dx.doi.org/10.1007/s11517-006-0061-1 ER -