Evolution of a Lytic Bacteriophage via DNA Acquisition from the Lactococcus lactis Chromosome Export

@article{citeulike:3801213, abstract = {We discovered a phage-host interaction in which the lytic phage ul36, in response to pressure exerted by an abortive phage resistance mechanism, acquired a large DNA fragment from the chromosome of Lactococcus lactis NCK203 to form a new phage, ul37. Phage ul37 was characterized at morphological, phenotypic, and genotypic levels and was found to be a member of the P335 species. Although it exhibits a high level of DNA homology with ul36, phage ul37 is resistant to the abortive mechanism and has a longer tail, a different base plate, and apparently a different origin of replication. The chromosomal DNA implicated in the formation of new phage ul37 was disrupted by site-specific integration in NCK203. This strategy prevented the appearance of ul37 during subsequent infections with ul36.}, author = {Moineau, Sylvain and Pandian, Sithian and Klaenhammer, Todd R.}, citeulike-article-id = {3801213}, citeulike-linkout-0 = {http://aem.asm.org/cgi/content/abstract/60/6/1832}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16349277}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16349277}, day = {1}, journal = {Appl. Environ. Microbiol.}, keywords = {lactis, lactococcus, lytic}, month = {June}, number = {6}, pages = {1832--1841}, posted-at = {2008-12-17 12:12:01}, priority = {2}, title = {Evolution of a Lytic Bacteriophage via DNA Acquisition from the Lactococcus lactis Chromosome}, url = {http://aem.asm.org/cgi/content/abstract/60/6/1832}, volume = {60}, year = {1994} }

TY - JOUR ID - citeulike:3801213 L3 - citeulike-article-id:3801213 N2 - We discovered a phage-host interaction in which the lytic phage ul36, in response to pressure exerted by an abortive phage resistance mechanism, acquired a large DNA fragment from the chromosome of Lactococcus lactis NCK203 to form a new phage, ul37. Phage ul37 was characterized at morphological, phenotypic, and genotypic levels and was found to be a member of the P335 species. Although it exhibits a high level of DNA homology with ul36, phage ul37 is resistant to the abortive mechanism and has a longer tail, a different base plate, and apparently a different origin of replication. The chromosomal DNA implicated in the formation of new phage ul37 was disrupted by site-specific integration in NCK203. This strategy prevented the appearance of ul37 during subsequent infections with ul36. IS - 6 JF - Appl. Environ. Microbiol. EP - 1841 TI - Evolution of a Lytic Bacteriophage via DNA Acquisition from the Lactococcus lactis Chromosome VL - 60 SP - 1832 KW - lactis KW - lactococcus KW - lytic AU - Moineau, Sylvain AU - Pandian, Sithian AU - Klaenhammer, Todd PY - 1994/06/01/ UR - http://aem.asm.org/cgi/content/abstract/60/6/1832 ER -