Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium Export

@article{citeulike:3801244, abstract = {Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E. faecalis and E. faecium (including vancomycin-resistant strains), as well as other human pathogens. We propose its development and use as an alternative therapeutic tool. 10.1128/JB.186.14.4808-4812.2004}, author = {Yoong, Pauline and Schuch, Raymond and Nelson, Daniel and Fischetti, Vincent A.}, citeulike-article-id = {3801244}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/JB.186.14.4808-4812.2004}, citeulike-linkout-1 = {http://jb.asm.org/cgi/content/abstract/186/14/4808}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15231813}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15231813}, day = {15}, doi = {10.1128/JB.186.14.4808-4812.2004}, journal = {J. Bacteriol.}, keywords = {enterococcus, faecalis, faecium}, month = {July}, number = {14}, pages = {4808--4812}, posted-at = {2008-12-17 12:25:12}, priority = {2}, title = {Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium}, url = {http://dx.doi.org/10.1128/JB.186.14.4808-4812.2004}, volume = {186}, year = {2004} }

TY - JOUR ID - citeulike:3801244 L3 - citeulike-article-id:3801244 N2 - Enterococcus faecalis and Enterococcus faecium infections are increasingly difficult to treat due to high levels of resistance to antibiotics. PlyV12, a bacteriophage lytic enzyme, was isolated and shown to effectively kill both E. faecalis and E. faecium (including vancomycin-resistant strains), as well as other human pathogens. We propose its development and use as an alternative therapeutic tool. 10.1128/JB.186.14.4808-4812.2004 IS - 14 JF - J. Bacteriol. EP - 4812 TI - Identification of a Broadly Active Phage Lytic Enzyme with Lethal Activity against Antibiotic-Resistant Enterococcus faecalis and Enterococcus faecium VL - 186 SP - 4808 KW - enterococcus KW - faecalis KW - faecium AU - Yoong, Pauline AU - Schuch, Raymond AU - Nelson, Daniel AU - Fischetti, Vincent PY - 2004/07/15/ UR - http://dx.doi.org/10.1128/JB.186.14.4808-4812.2004 ER -