Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Export

@article{citeulike:1198910, abstract = {The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.}, author = {Brightbill, H. D. and Libraty, D. H. and Krutzik, S. R. and Yang, R. B. and Belisle, J. T. and Bleharski, J. R. and Maitland, M. and Norgard, M. V. and Plevy, S. E. and Smale, S. T. and Brennan, P. J. and Bloom, B. R. and Godowski, P. J. and Modlin, R. L.}, citeulike-article-id = {1198910}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.285.5428.732}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/285/5428/732}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/10426995}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=10426995}, day = {30}, doi = {10.1126/science.285.5428.732}, issn = {0036-8075}, journal = {Science (New York, N.Y.)}, keywords = {danger-signal, immune, innate\_immune\_system, pathogen, tlr}, month = {July}, number = {5428}, pages = {732--736}, posted-at = {2009-11-03 15:21:12}, priority = {2}, title = {Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.}, url = {http://dx.doi.org/10.1126/science.285.5428.732}, volume = {285}, year = {1999} }

TY - JOUR ID - citeulike:1198910 L3 - citeulike-article-id:1198910 N2 - The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens. IS - 5428 JF - Science (New York, N.Y.) SN - 0036-8075 EP - 736 TI - Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. VL - 285 SP - 732 KW - danger-signal KW - immune KW - innate_immune_system KW - pathogen KW - tlr AU - Brightbill, HD AU - Libraty, DH AU - Krutzik, SR AU - Yang, RB AU - Belisle, JT AU - Bleharski, JR AU - Maitland, M AU - Norgard, MV AU - Plevy, SE AU - Smale, ST AU - Brennan, PJ AU - Bloom, BR AU - Godowski, PJ AU - Modlin, RL PY - 1999/07/30/ UR - http://dx.doi.org/10.1126/science.285.5428.732 ER -